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GPR120 Compound A
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产品介绍
产品介绍
产品信息
抗原名称
GPR120
商品描述
GPR120 compound A is an orally available, high-affinity agonist of GPR120 (EC50 = ~0.35 μm) that demonstrates potent selectivity over another lipid-sensing G-protein, GPR40 (FFAR1).
分子量
405.8
纯度
>98%
可溶性
DMSO : ≥ 50 mg/mL (123.20 mM)
外观
Powder
In vitro(体外研究)
GPR120-IN-1 is fully selective for Gpr120 (logEC50=−7.62) with negligible activity towards Gpr40. GPR120-IN-1 produces concentration dependent increases in IP3 production from both human and mouse Gpr120 expressing cells. GPR120-IN-1 leads to a concentration-dependent response to recruit β-arrestin-2 in both human and mouse Gpr120 expressing cells, with EC50s of ~0.35 μM. GPR120-IN-1 strongly and comparably inhibits LPS-induced phosphorylation of Tak1, Ikkβ, and Jnk and blocked IκB degradation .
In vivo(体内研究)
GPR120-IN-1 causes improved insulin sensitivity with increased glucose infusion rates, enhanced insulin stimulated-glucose disposal rate, along with a marked increase in the ability of insulin to suppress hepatic glucose production only in WT mice. GPR120-IN-1 treatment has beneficial effects on hepatic lipid metabolism, causing decreased hepatic steatosis, decreased liver triglycerides, and DAGs, along with reduced saturated free fatty acid conten.
背景
别名
GPR120 cpdA；GPR120-IN-1；MDK-77754; MDK 77754；GPR120 Agonist 3
分子式
C19H23ClF3NO3
CAS号
1599477-75-4
制备和贮存
保存方式
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
参考图片
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