GS 39783 (10 mg)

6604928

Positive allosteric modulator of GABA_B receptors

337.44

N,N'-Dicyclopentyl-2-(methylthio)-5-nitro-4,6-pyrimidinediamine

Potent and selective L-type voltage-gated Ca²⁺ channel blocker. EC₅₀ and pA₂ values are 1.4 nM and 10.3 for relaxation of depolarization- and Ca²⁺-induced contractions of rabbit aorta respectively; EC₂₅ = 0.45 nM for reduction in rate of spontaneously beating guinea pig right atria. Long-acting antihypertensive agent in vivo, exerting primary effects on vascular tissue with secondary negative chronotropic action.

≥98% (HPLC)

Soluble to 50 mM in DMSO and to 20 mM in ethanol

CSC1=NC(NC2CCCC2)=C(C(NC2CCCC2)=N1)[N+]([O-])=O

C₁₅H₂₃N₅O₂S

39069-52-8