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GSA 10
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产品介绍
产品介绍
产品信息
商品描述
Smoothened (SMO) is a cell surface receptor that, with Patched, mediates hedgehog signaling to regulate gene expression through the Gli transcription factors. GSA 10 is a quinolinecarboxamide derivative that acts as an agonist of SMO. By acting at SMO, GSA 10 has been shown to promote the differentiation of multipotent mesenchymal progenitor cells into osteoblasts (EC50 = 1.2 µM). Most notably, GSA 10 does not recognize the classic cyclopamine binding site as do other SMO agonists and as such has been used to characterize a novel SMO active site.
分子量
450.5
纯度
≥95%
可溶性
Soluble in DMSO (0.5 mg/ml), DMF (~1 mg/ml), and aqueous solutions (sparingly).
外观
solid
背景
别名
GSA-10
分子式
C26H30N2O5
CAS号
300833-95-8
制备和贮存
保存方式
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
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