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产品介绍
产品介绍
产品信息
商品描述
GSK-3 Inhibitor II is a potent inhibitor of GSK-3β (glycogen synthase kinase-3β) (IC50=390 nM). GSK-3 was first discovered to be involved in the control of glycogen metabolism, but has since been indicated in regulating a diverse range of cellular functions, such as neuronal cell survival and death. GSK-3β plays an important role in cardiomyopathies and has been shown to decrease MRP2 expression in neuronal growth factor (NGF)-induced PC-12 cells . Activation of GSK-3β plays a critical role in diabetes-related changes in cardiac energy metabolism, inflammation, nitrosative damage, and remodeling.
分子量
395.2
纯度
≥98%
可溶性
Soluble in DMSO (10 mg/ml), and ethanol.
背景
别名
TIBPO; 2-Thio(3-iodobenzyl)-5-(1-pyridyl)-[1,3,4]-oxadiazole
分子式
C14H10IN3OS
CAS号
478482-75-6
制备和贮存
保存方式
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
参考图片
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