GW 9508 (10 mg)

11595431

Potent and selective FFA1 (GPR40) agonist

347.41

4-[[(3-Phenoxyphenyl)methyl]amino]benzenepropanoic acid

Potent and selective agonist for the free fatty acid receptor FFA1 (GPR40) (pEC₅₀ values are 7.32, < 4.3 and < 4.3 for FFA1, FFA2 and FFA3 receptors respectively). Inactive against a range of other GPCRs, kinases, proteases, integrins and PPARs. Potentiates glucose-stimulated insulin secretion in MIN6 cells (pEC₅₀ = 6.14).

≥99% (HPLC)

Soluble to 100 mM in DMSO and to 100 mM in ethanol

OC(=O)CCC1=CC=C(NCC2=CC=CC(OC3=CC=CC=C3)=C2)C=C1

C₂₂H₂₁NO₃

885101-89-3