GW 9662 (10 mg)

644213

Selective covalent PPARγ antagonist

276.68

2-Chloro-5-nitro-N-phenylbenzamide

Selective PPARγ antagonist (IC₅₀ values are 3.3, 32 and 2000 nM for PPARγ, PPARα and PPARδ respectively). Blocks the inhibition of osteoclast formation induced by IL-4 in the low micromolar range (1-2 μM), therefore is more potent than BADGE (Cat. No. 1326). Anticancer, inhibits growth of human mammary tumor cell lines.

≥98% (HPLC)

Soluble to 25 mM in ethanol with gentle warming and to 100 mM in DMSO

[O-][N+](=O)C1=CC(C(=O)NC2=CC=CC=C2)=C(Cl)C=C1

C₁₃H₉N₂O₃Cl

22978-25-2