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H-151
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产品介绍
产品介绍
产品信息
抗原名称
STING
商品描述
H-151 is a highly potent, selective and covalent antagonist of STING, reduces TBK1 phosphorylation and suppresses human STING palmitoylation.
分子量
279.34
纯度
98%
可溶性
DMSO : 125 mg/mL (447.48 mM; Need ultrasonic)
外观
White to off-white solid
In vitro(体外研究)
H-151 (0.02-2 μM) reduces IFNβ luciferase reporter measurements of HEK293T cells. H-151 (0.5 μM; 2 h) inhibits the phosphorylation of TBK1 in THP-1 cells. H-151 (1 μM; 3 h) suppresses hsSTING palmitoylation.
In vivo(体内研究)
H-151 (750 nmol per mouse; a single i.p.) markedly reduces systemic cytokine responses in CMA-treated mice. H-151 (750 nmol per mouse; i.p. daily for 7 d) exhibits notable efficacy in Trex1−/− mice that expressed a bioluminescent IFNβ reporter. H-151 (750 nmol per mouse; i.p.) reaches effective systemic levels, displays a short half-life in the serum and forms an adduct to mmSTING in wild-type mice.
背景
分子式
C17H17N3O
CAS号
941987-60-6
制备和贮存
保存方式
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
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