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BD OptiBuild™ RY586 Mouse Anti-Mouse H-2K[b]/H-2D[b]

品牌： BD Pharmingen

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反应种属：

Mouse (Tested in Development)

来源宿主：

Mouse C3H, also known as C3H/He, C3H/Bi IgG2a, κ

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产品介绍

产品信息

耦联标记

RY586

抗原名称

H-2Kb, H-2Db

宿主

Mouse C3H, also known as C3H/He, C3H/Bi IgG2a, κ

免疫原

C3H.SW mouse splenocytes

简单描述

The 28-8-6 monoclonal antibody specifically recognizes the H-2K[b] and H-2D[b] MHC class I alloantigens. The reaction with H-2K[b] has been reported to be stronger than that with H-2D[b]. Its recognition of H-2D[b] is dependent upon the presence of β2 microglobulin. Cross-reactivity with an epitope on the N-terminal domains, α1 and α2, of the H-2D[d] MHC class I alloantigen has also been described. Reactivity with other haplotypes ( e.g., f, k, p, q, r, s ) has not been observed.

商品描述

28-8-6 The 28-8-6 monoclonal antibody specifically recognizes the H-2K[b] and H-2D[b] MHC class I alloantigens. The reaction with H-2K[b] has been reported to be stronger than that with H-2D[b]. Its recognition of H-2D[b] is dependent upon the presence of β2 microglobulin. Cross-reactivity with an epitope on the N-terminal domains, α1 and α2, of the H-2D[d] MHC class I alloantigen has also been described. Reactivity with other haplotypes ( e.g., f, k, p, q, r, s ) has not been observed.

同种型

Mouse C3H, also known as C3H/He, C3H/Bi IgG2a, κ

克隆号

克隆 28-8-6 (RUO)

浓度

0.2 mg/ml

产品详情

RY586

The BD Horizon RealYellow™ 586 (RY586) Dye is part of the BD family of yellow-green dyes. It is a small organic fluorochrome with an excitation maximum (Ex Max) at 565-nm and an emission maximum (Em Max) at 586-nm. Driven by BD innovation, RY586 can be used on both spectral and conventional cytometers and is designed to be excited by the Yellow-Green laser (561-nm) with minimal excitation by the 488-nm Blue laser. For conventional instruments equipped with a Yellow-Green laser (561-nm), RY586 can be used as an alternative to PE and we recommend using an optical filter centered near 586-nm (eg, a 586/15-nm bandpass filter). For spectral instruments equipped with a Yellow-Green laser (561-nm), it can be used in conjunction with PE. Compared to PE, RY586 is similar in brightness, minimal spillover into Blue detectors, and increased spillover into the 610/20-nm (PE-CF594) detector. Please ensure that your instrument configuration (lasers and optical filters) is appropriate for this dye.

格式:RY586

激发源:Yellow-Green 561 nm

最多激发源:564 nm

最多发射源:586 nm

应用

实验应用

Flow cytometry (Qualified)

反应种属

Mouse (Tested in Development)

目标/特异性

H-2Kb, H-2Db

背景

别名

H-2Kb; H-2Db; Histocompatibility-2Kb; Histocompatibility-2Db

制备和贮存

存储溶液

Aqueous buffered solution containing ≤0.09% sodium azide.

保存方式

Aqueous buffered solution containing ≤0.09% sodium azide.

文献

研发参考(3) 1. Allen H, Fraser J, Flyer D, Calvin S, Flavell R. Beta 2-microglobulin is not required for cell surface expression of the murine class I histocompatibility antigen H-2Db or of a truncated H-2Db. Proc Natl Acad Sci U S A. 1986; 83(19):7447-7451. (Biology). 2. Evans GA, Margulies DH, Shykind B, Seidman JG, Ozato K. Exon shuffling: mapping polymorphic determinants on hybrid mouse transplantation antigens. Nature. 1982; 300(5894):755-757. (Biology). 3. Ozato K, Sachs DH. Monoclonal antibodies to mouse MHC antigens. III. Hybridoma antibodies reacting to antigens of the H-2b haplotype reveal genetic control of isotype expression. J Immunol. 1981; 126(1):317-321. (Immunogen).

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货号：

753627

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