R&D Systems_h/prGDF-15 Biot Aff (50 ug)

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h/prGDF-15 Biot Aff (50 ug)

货号： BAF940 品牌： R&D Systems 反应种属：

Human

应用：

Western Blot(0.1 µg/mL)
ELISA Capture (Matched Antibody Pair)(2-8 µg/mL )
ELISA Detection (Matched Antibody Pair)(0.1-0.4 µg/mL )
ELISA Standard ( )

规格： 50ug

产品说明书

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价格: ¥5919.00

数量

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产品信息

耦联标记

Biotin

纯化方式

Antigen Affinity-purified

目标/特异性

Detects human GDF-15 in ELISAs and Western blots. In sandwich immunoassays, less than 0.1% cross-reactivity with recombinant human GDF‑11, recombinant mouse (rm) GDF-5, rmGDF-6, rmGDF-7, and rmGDF-8 is observed.

商品描述

For ELISA the Antibody Pairs information：Capture antibody：MAB957；Detection antibody：BAF940; and protein: 957-GD-025

产品形式

Reconstitute at 0.2 mg/mL in sterile PBS.

应用

实验应用

Western Blot(0.1 µg/mL)
ELISA Capture (Matched Antibody Pair)(2-8 µg/mL )
ELISA Detection (Matched Antibody Pair)(0.1-0.4 µg/mL )
ELISA Standard ( )

反应种属

Human

背景

Growth Differentiation Factor 15 (GDF-15), also called Macrophage inhibitory cytokine-1 (MIC-1), placental transforming growth factor-beta, prostate-derived factor, and placental bone morphogenetic protein, is a divergent member of the transforming growth factor beta (TGF-beta ) superfamily. GDF-15 is highly expressed in placenta and is expressed at lower levels in kidney, pancreas, prostate and colon. It is also widely expressed in brain. Similar to other TGF-beta family proteins, GDF-15 is synthesized as a large precursor protein that is cleaved at the dibasic cleavage site (RXXR) to release the carboxy-terminal domain. The carboxy-terminal domain of GDF-15 contains the characteristic seven conserved cysteine residues necessary for the formation of the cysteine knot and the single interchain disulfide bond. Furthermore, the carboxy-terminal domain contains two additional cysteine residues that form a fourth intrachain disulfide bond. Biologically active GDF-15 is a disulfide-linked homodimer of the carboxy-terminal 112 amino acid residues. Mature human GDF-15 shares 66.1% and 68.7% amino acid sequence similarity with rat and mouse GDF-15, respectively, which are remarkably low homologies between species in TGF-beta superfamily. GDF-15 has been shown to have various functions, including inhibition of production of tumor necrosis factor alpha (TNF-alpha ) from lipopolysaccharide-stimulated macrophages, induction of cartilage formation, early-stage endochonadal bone formation, and promotion of neuronal survival.

别名

growth differentiation factor 15; growth/differentiation factor 15; Macrophage inhibitory cytokine 1; MIC-1; MIC-1NSAID-activated gene 1 protein; MIC1Prostate differentiation factor; NAG-1; NAG-1NSAID-regulated gene 1 protein; NSAID (nonsteroidal inflammatory drug)-activated protein 1; PDF; PDFGDF-15; PLAB; PLABNRG-1; Placental bone morphogenetic protein; Placental TGF-beta; PTGF-beta; PTGFBPTGF-beta

制备和贮存

溶解方法

Reconstitute at 0.2 mg/mL in sterile PBS.

文献

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

AF1q: A Novel Mediator of Basal and 4-HPR-Induced Apoptosis in Ovarian Cancer Cells.
Authors: Tiberio P, Cavadini E, Callari M
PLoS ONE, 2012;7(6):e39968.
Species: Human
Sample Type: Cell Lysates
Application: WB
Growth differentiation factor-15 predicts mortality and morbidity after cardiac resynchronization therapy.
Authors: Foley PW, Stegemann B, Ng K, Ramachandran S, Proudler A, Frenneaux MP, Ng LL, Leyva F
Eur. Heart J., 2009;30(22):2749-57.
Species: Human
Sample Type: Plasma
Application: ELISA Development
Growth differentiation factor-15 as a prognostic marker in patients with acute myocardial infarction.
Authors: Khan SQ, Ng K, Dhillon O, Kelly D, Quinn P, Squire IB, Davies JE, Ng LL
Eur. Heart J., 2009;30(9):1057-65.
Species: Human
Sample Type: Plasma
Application: ELISA Development

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