HAT1 Antibody

Histone acetyltransferase 1 (HAT1) is a member of the GCN5 family of acetyltransferases that can acetylate Lys5 and Lys12 on newly generated histone H4, a process that is essential for mammalian development (1-5). HAT1 binds to the H4 gene promoter, where it facilitates the production and acetylation of new histones. This process is strongly dependent on glucose availability, suggesting HAT1 plays a role in nutrient sensing (6). HAT1 has also been shown to contribute to recovery from replication-based DNA damage by incorporating H4Lys5/Lys12 acetylated histones at the sites of double-stranded breaks (7-9). HAT1 can acetylate non-histone proteins as well, and has been shown to play a key role in NF-kB signaling by acetylating PLZF, which in turn forms a complex with p50 to limit the production of cytokines (10). HAT1 overexpression has also been implicated in many cancer types (11-13). 1.Kleff, S. et al. (1995) J Biol Chem 270, 24674-7. 2.Verreault, A. et al. (1998) Curr Biol 8, 96-108. 3.Ruiz-García, A.B. et al. (1998) J Biol Chem 273, 12599-605. 4.Dutnall, R.N. et al. (1998) Cell 94, 427-38. 5.Nagarajan, P. et al. (2013) PLoS Genet 9, e1003518. 6.Gruber, J.J. et al. (2019) Mol Cell 75, 711-724.e5. 7.Barman, H.K. et al. (2006) Biochem Biophys Res Commun 345, 1547-57. 8.Benson, L.J. et al. (2007) J Biol Chem 282, 836-42. 9.Yang, X. et al. (2013) J Biol Chem 288, 18271-82. 10.Sadler, A.J. et al. (2015) Nat Commun 6, 6795. 11.Min, S.K. et al. (2012) Korean J Pathol 46, 142-50. 12.Miao, B.P. et al. (2018) Arch Biochem Biophys 646, 72-79. 13.Fan, P. et al. (2019) J Exp Clin Cancer Res 38, 47.