HS1 (D5A9) Rabbit mAb

HS1 (HCLS1, LckBP1, p75) is a protein kinase substrate that is expressed only in tissues and cells of hematopoietic origin (1,2). HS1 contains four cortactin repeats and a single SH3 domain (2). This intracellular protein is phosphorylated following immune receptor activation, which promotes recruitment of HS1 to the immune synapse (3-5). Phosphorylation of HS1 is required to regulate actin dynamics and provide docking sites for many other signaling molecules, such as Vav1 and PLCγ1 (6). HS1 also plays an important role in platelet activation (7). 1.Kitamura, D. et al. (1989) Nucleic Acids Res 17, 9367-79. 2.Kitamura, D. et al. (1995) Biochem Biophys Res Commun 208, 1137-46. 3.Suzuki, H. et al. (1997) J Immunol 159, 5881-8. 4.Hata, D. et al. (1994) Immunol Lett 40, 65-71. 5.Yamanashi, Y. et al. (1993) Proc Natl Acad Sci USA 90, 3631-5. 6.Gomez, T.S. et al. (2006) Immunity 24, 741-52. 7.Kahner, B.N. et al. (2007) Blood 110, 2449-56.