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产品介绍
产品介绍
产品信息
纯化方式
Affinity purified on immobilized antigen.
宿主
Rabbit
免疫原
Peptide (C)EEAGPAGEPRGSQAS, corresponding to amino acid residues 147-161 of human HCN2 (Accession Q9UL51). Intracellular, N-terminus.
简单描述
A Rabbit Polyclonal Antibody to HCN2 Conjugated to the Fluorescent Dye ATTO-594
商品描述
Anti-HCN2 Antibody (#APC-030) is a highly specific antibody directed against an epitope of the human protein. The antibody can be used in western blot, immunoprecipitation, immunohistochemistry, and immunocytochemistry applications. It has been designed to recognize HCN2 from human, rat, and mouse samples.
同种型
Rabbit IgG.
纯度
Affinity purified on immobilized antigen.
形式
Lyophilized
组成成分
免疫球蛋白G型抗体
基因
HCN2
应用
实验应用
IF, IHC
反应种属
H, M, R
背景
别名
Hyperpolarization-activated cyclic nucleotide-gated potassium channel 2, BCNG2, HAC-1
背景
Hyperpolarization-activated cation currents (Ih) appear in the heart and the brain having crucial role in controlling electrical pacemaker activity, contributing to biological processes such as heartbeat, sleep-wake cycle and synaptic plasticity.1,2
The Ih currents are generated by the Hyperpolarization-activated cyclic nucleotide-gated cannel family (HCN), which comprises of four homologous members, named HCN1-4. Each HCN subunit consist of six transmembrane domains (TM), a pore region between TM5-TM6 and a binding domain to cyclic nucleotides (CNBD) in the cytoplasmic C-terminus.2
The HCN subunits can form functionally homomers and can also co-assemble into functionally heteromers.2
The channels are closely related to each other and share homology of about 60%. However, they are diverging from each other in their cytoplasmic N- and the C-terminus. The channels HCN1-4 mainly differ from each other with regard to their speed of activation and the extent by which they are modulated by cAMP. HCN1 is the fastest channel, followed by HCN2, HCN3 and HCN4.2,3
HCN2 is the most abundant neuronal channel and is found almost ubiquitously in the brain.3
The Ih currents are generated by the Hyperpolarization-activated cyclic nucleotide-gated cannel family (HCN), which comprises of four homologous members, named HCN1-4. Each HCN subunit consist of six transmembrane domains (TM), a pore region between TM5-TM6 and a binding domain to cyclic nucleotides (CNBD) in the cytoplasmic C-terminus.2
The HCN subunits can form functionally homomers and can also co-assemble into functionally heteromers.2
The channels are closely related to each other and share homology of about 60%. However, they are diverging from each other in their cytoplasmic N- and the C-terminus. The channels HCN1-4 mainly differ from each other with regard to their speed of activation and the extent by which they are modulated by cAMP. HCN1 is the fastest channel, followed by HCN2, HCN3 and HCN4.2,3
HCN2 is the most abundant neuronal channel and is found almost ubiquitously in the brain.3
制备和贮存
溶解方法
50 µl double distilled water (DDW).
保存方式
The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C.
数据库链接
Entrez-Gene ID
114244
UniProt ID
Q9UL51
研究资源识别码
AB_2341028.
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