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产品介绍
产品介绍
产品信息
荧光素标记
Unconjugated
抗原名称
Hexokinase I
来源纯化
Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Glu108 of human hexokinase I protein.
宿主
Rabbit
商品描述
Product Usage Information
| Application | Dilution |
|---|---|
| Western Blotting | 1:1000 |
| Immunoprecipitation | 1:50 |
| Immunohistochemistry (Paraffin) | 1:800 |
| Immunofluorescence (Frozen) | 1:800 - 1:1600 |
| Immunofluorescence (Immunocytochemistry) | 1:200 |
| Flow Cytometry (Fixed/Permeabilized) | 1:200 - 1:800 |
同种型
Rabbit IgG
分子量
102
研究领域
癌症,纤维化,代谢,神经科学,
应用
反应种属
Human,Mouse,
目标/特异性
Specificity/Sensitivity
Hexokinase I (C35C4) Rabbit mAb detects endogenous levels of total hexokinase I protein.
Species Reactivity:
Human, Mouse
敏感性
Endogenous
背景
背景
Hexokinase catalyzes the conversion of glucose to glucose-6-phosphate, the first step in glycolysis. Four distinct mammalian hexokinase isoforms, designated as hexokinase I, II, III, and IV (glucokinase), have been identified. Hexokinases I, II, and III are associated with the outer mitochondrial membrane and are critical for maintaining an elevated rate of aerobic glycolysis in cancer cells (Warburg Effect) (1) in order to compensate for the increased energy demands associated with rapid cell growth and proliferation (2,3).
1.WARBURG, O. (1956) Science 123, 309-14.
2.Semenza, G.L. (2000) Crit Rev Biochem Mol Biol 35, 71-103.
3.Smith, T.A. (2000) Br J Biomed Sci 57, 170-8.
研究领域
癌症,纤维化,代谢,神经科学,
翻译后修饰
unmodified
制备和贮存
保存方式
Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.
For a carrier free (BSA and azide free) version of this product see product #75806.
数据库链接
Entrez-Gene ID
3098
UniProt ID
P19367
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