Hippo Signaling Antibody Sampler Kit

Hippo signaling is an evolutionarily conserved pathway that controls cell proliferation, apoptosis, and organ size in response to changing cell density levels (1,2). At relative low cell density, transcription co-activators YAP and TAZ bind transcription factors to induce expression of genes that favor cell growth and proliferation. As cell density increases, interaction between membrane-bound upstream hippo pathway regulators trigger activation of cytoplasmic kinases Mst1/2 and LATS1/2. Activated Mst kinase (the eponymous Hippo in Drosophila) associates with the adaptor Sav1 and phosphorylates MOB1 to activate LATS kinase, which phosphorylates YAP and TAZ to suppress cell proliferation (3). 1.McNeill, H. and Woodgett, J.R. (2010) Nat Rev Mol Cell Biol 11, 404-13. 2.Zeng, Q. and Hong, W. (2008) Cancer Cell 13, 188-92. 3.Zhao, B. et al. (2007) Genes Dev 21, 2747-61.