HMGA1 (D6A4) XP ® Rabbit mAb

HMGA1, formerly known as HMG-I/Y, belongs to a family of high mobility group proteins that contain an AT-hook DNA binding domain. HMGA proteins are considered architectural transcription factors; they do not have direct transcriptional activation capacity, but instead regulate gene expression by changing DNA conformation through binding to AT-rich regions in the DNA and/or direct interaction with other transcription factors (1,2). HMGA1 is highly expressed during embryogenesis and in embryonic stem cells, but not in fully differentiated adult tissues (2-4). Research studies have shown that HMGA1 is over-expressed in rapidly dividing neoplastic cells and a wide variety of aggressive cancers, including thyroid, colon, breast, pancreas, and prostate (2-4). Investigators have shown that forced expression of HMGA1 induces cellular transformation and an epithelial-to-mesenchymal transition (EMT), while inhibition of HMGA1 expression blocks anchorage-independent cell growth and proliferation of cancer cells, suggesting that HMGA1 contributes to carcinogenesis by inducing and maintaining a de-differentiated, highly proliferative cell state (5-8). 1.Cleynen, I. and Van de Ven, W.J. (2008) Int J Oncol 32, 289-305. 2.Resar, L.M. (2010) Cancer Res 70, 436-9. 3.Chiappetta, G. et al. (1996) Oncogene 13, 2439-46. 4.Ben-Porath, I. et al. (2008) Nat Genet 40, 499-507. 5.Wood, L.J. et al. (2000) Mol Cell Biol 20, 5490-502. 6.Wood, L.J. et al. (2000) Cancer Res 60, 4256-61. 7.Xu, Y. et al. (2004) Cancer Res 64, 3371-5. 8.Scala, S. et al. (2000) Proc Natl Acad Sci U S A 97, 4256-61.