HMGA2 (D1A7) Rabbit mAb

HMGA2 belongs to the family of high mobility group with AT-hook DNA binding domain. HMGA proteins are considered architectural transcription factors; they do not have direct transcriptional activation capacity, but instead regulate gene expression by changing DNA conformation through binding to AT-rich regions in the DNA and/or direct interaction with other transcription factors (1,2). HMGA2 is abundantly and ubiquitously expressed and plays a crucial role during embryonic development (3). HMGA2 promotes stem cell self-renewal and research studies have shown that decreased HMGA2 expression is associated with stem cell aging (2,4-6). Investigators have shown that expression levels of HMGA2 are very low in normal adult tissues, while either overexpression or rearrangement is associated with many types of cancer (7-10). 1.Cleynen, I. and Van de Ven, W.J. (2008) Int J Oncol 32, 289-305. 2.Pfannkuche, K. et al. (2009) Stem Cell Rev 5, 224-30. 3.Monzen, K. et al. (2008) Nat Cell Biol 10, 567-74. 4.Nishino, J. et al. (2008) Cell 135, 227-39. 5.Li, O. et al. (2006) Genesis 44, 523-9. 6.Li, O. et al. (2007) FEBS Lett 581, 3533-7. 7.Fusco, A. and Fedele, M. (2007) Nat Rev Cancer 7, 899-910. 8.Rawlinson, N.J. et al. (2008) Cancer Genet Cytogenet 181, 119-24. 9.Wei, J.J. et al. (2010) Am J Surg Pathol 34, 18-26. 10.Mahajan, A. et al. (2010) Mod Pathol 23, 673-81.