hnRNP M (E3J6F) Rabbit mAb

Heterogenous nuclear ribonucleoprotein M (hnRNP M) belongs to a family of RNA-binding multi-protein complexes (hnRNP proteins) that facilitate pre-mRNA processing (1,2). hnRNP M binds to GU rich regions of RNA and exists as 4 isoforms named M1-M4 (2). Binding to pre-mRNA in early stages of spliceosome assembly, hnRNP M contributes to splicing events by inducing exon skipping as well as promoting exon inclusion (3,4). hnRNP M is expressed on the surface of Kupffer cells, and acts as a receptor for carcinoembryonic antigen (CEA), a biomarker for colorectal cancer metastasis to the liver (5-7). hnRNP M has also shown to be a key regulator of the innate immune response in macrophages, where it represses key inflammatory and antimicrobial genes (8,9). 1.Dreyfuss, G. et al. (1993) Annu Rev Biochem 62, 289-321. 2.Datar, K.V. et al. (1993) Nucleic Acids Res 21, 439-46. 3.Kafasla, P. et al. (2002) Biochem J 363, 793-9. 4.Hovhannisyan, R.H. and Carstens, R.P. (2007) J Biol Chem 282, 36265-74. 5.Bajenova, O. et al. (2003) Exp Cell Res 291, 228-41. 6.Laguinge, L. et al. (2005) Anticancer Res 25, 23-31. 7.Thomas, P. et al. (2011) Clin Exp Metastasis 28, 923-32. 8.Cao, P. et al. (2019) PLoS Pathog 15, e1007983. 9.West, K.O. et al. (2019) Cell Rep 29, 1594-1609.e5.