HRP Anti-CD53 antibody [EPR4342(2)]

HRP

Structural component of specialized membrane microdomains known as tetraspanin-enriched microdomains (TERMs), which act as platforms for receptor clustering and signaling (PubMed : 28487417). Participates thereby in diverse biological functions such as cell signal transduction, adhesion, migration and protein trafficking (PubMed : 32974937, PubMed : 35767951). Plays a role in the activation of monocytes and B-cells (PubMed : 8335905). Acts as an essential regulator of B-cell development by promoting interleukin-7 receptor/IL7R signaling (By similarity). Promotes also in B-cells the BCR signaling by recruiting PKC to the plasma membrane in order to phosphorylate its substrates (PubMed : 28487417). Plays an essential role in B- and T-cells homing to lymph nodes by stabilizing L-selectin/SELL cell surface expression (By similarity). Mediates also metabolic and inflammatory functions in hepatocytes and adipose tissue by promoting TNF-alpha and LPS signaling independent of the immune compartment (By similarity).

Rabbit

Synthetic peptide. This information is proprietary to Abcam and/or its suppliers.

HRP兔单克隆抗体[EPR4342(2)] to CD53

IgG

EPR4342(2)

单克隆

Protein A purified

Liquid

免疫学和肿瘤学

Target Binding Affinity, Antibody Labelling

CD53, MOX44, TSPAN25, Leukocyte surface antigen CD53, Cell surface glycoprotein CD53, Tetraspanin-25, Tspan-25

pH: 7.40Preservative: 0.1% Proclin 300 SolutionConstituents: 30% Glycerol (glycerin, glycerine), 1% BSA, 68% PBS

P19397