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Rabbit anti-Phospho-HSF1(Ser307) Polyclonal Antibody
品牌： Absin
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对比
咨询分子量：
Detects a band of approximately: 75-80kDa(Predicted molecular weight: 57kDa)
反应种属：
Mouse
产品介绍
产品介绍
产品信息
荧光素标记
Unlabeled
纯化方式
affinity purified by Protein A
宿主
Rabbit
免疫原
KLH conjugated Synthesised phosphopeptide derived from human HSF1 around the phosphorylation site of Ser307(PQ(p-S)PR)
同种型
IgG
分子量
Detects a band of approximately: 75-80kDa(Predicted molecular weight: 57kDa)
克隆类别
Polyclonal Antibody
浓度
1mg/mL
应用
实验应用
WB: 1:500-2000
反应种属
Mouse
背景
别名
phospho-HSF1 (Ser307) 抗体
翻译后修饰
Phosphorylated
无
Phosphorylated on multiple serine residues, a subset of whichare involved in stress-related regulation of transcriptionactivation. Constitutive phosphorylation represses transcriptionalactivity at normal temperatures. Levels increase on specificresidues heat-shock and enhance HSF1 transactivation activity.Phosphorylation on Ser-307 derepresses activation on heat-stressand in combination with Ser-303 phosphorylation appears to beinvolved in recovery after heat-stress. Phosphorylated on Ser-230by CAMK2, in vitro. Cadmium also enhances phosphorylation at thissite. Phosphorylation on Ser-303 is a prerequisite for HSF1sumoylation. Phosphorylation on Ser-121 inhibits transactivationand promotes HSP90 binding. Phosphorylation on Thr-142 alsomediates transcriptional activity induced by heat.
细胞定位
细胞核,细胞浆
制备和贮存
存储溶液
0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存方式
Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
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