BD Pharmingen™ Purified Mouse Anti-Hsp70

Hsp70

Mouse IgG2b

Purified Hsp70

Cells from many organisms increase the expression of heat shock or stress proteins in response to adverse changes. The h eat s hock p rotein (HSP) 70 family consists of multiple members, localized within different intracellular compartments. HSP 70 is constitutively expressed in many human cells with increased expression observed following stress. Members of the HSP 70 family bind ATP, and are thought to function as molecular chaperones by assisting in the folding of other proteins in various intracellular compartments. HSP 70 migrates at a molecular weight of 70 kDa in SDS-PAGE. The 5G10 antibody recognizes human HSP 70. Purified HSP 70 was isolated from K562, a human erythroid cell line, and used as immunogen.

5G10 Cells from many organisms increase the expression of heat shock or stress proteins in response to adverse changes. The h eat s hock p rotein (HSP) 70 family consists of multiple members, localized within different intracellular compartments. HSP 70 is constitutively expressed in many human cells with increased expression observed following stress. Members of the HSP 70 family bind ATP, and are thought to function as molecular chaperones by assisting in the folding of other proteins in various intracellular compartments. HSP 70 migrates at a molecular weight of 70 kDa in SDS-PAGE. The 5G10 antibody recognizes human HSP 70. Purified HSP 70 was isolated from K562, a human erythroid cell line, and used as immunogen.

Mouse IgG2b

克隆 5G10 (RUO)

0.5 mg/ml

Western blot (Routinely Tested), Immunoprecipitation (Tested During Development)

Human (QC Testing)

Hsp70

Aqueous buffered solution containing ≤0.09% sodium azide.

研发参考(3) 1. Craig EA, Gross CA. Is hsp70 the cellular thermometer. Trends Biochem Sci. 1991; 16(4):135-140. (Biology). 2. Cyr DM, Langer T, Douglas MG. DnaJ-like proteins: molecular chaperones and specific regulators of Hsp70. Trends Biochem Sci. 1994; 19(4):176-181. (Biology). 3. Singh MK, Yu J. Accumulation of a heat shock-like protein during differentiation of human erythroid cell line K562. Nature. 1984; 309(5969):631-633. (Immunogen).