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产品介绍
产品介绍
产品信息
抗原名称
DYRK4:41.8 nM, mTOR:632 nM, CDK7:1230 nM, PIM1:60.6 nM
商品描述
HTH-01-091 is a potent and selective maternal embryonic leucine zipper kinase (MELK) inhibitor (IC50: 10.5 nM).HTH-01-091 inhibits PIM1/2/3, RIPK2, DYRK3, smMLCK and CLK2. HTH-01-091 can be used to study breast cancer.
分子量
499.43
纯度
98%
可溶性
DMSO:5 mg/mL (10 mM)
In vitro(体外研究)
HTH-01-091 (0-10 μM, 1 h) dose-dependently decreased MELK pull-down by streptavidin beads, demonstrating that the compound is cell permeable and binds to MELK in an ATP-competitive fashion causes MELK degradation.[1]
HTH-01-091 (1 μM) selectively inhibits 4% of the kinases over 90%[1].
HTH-01-091 (0-10 μM, 3 days) exhibits minor antiproliferative effects in breast cancer cells[1].
背景
分子式
C26H28Cl2N4O2
CAS号
2000209-42-5
制备和贮存
保存方式
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
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