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hRELT MAb (Cl 238104 (25 ug)

hRELT MAb (Cl 238104 (25 ug)

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品牌: R&D Systems
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来源宿主:
Mouse IgG2b
实验应用:
Flow Cytometry(0.25 µg/106 cells)
产品介绍
产品介绍
产品信息
荧光素标记
纯化方式
Protein A or G purified from hybridoma culture supernatant
抗原名称
Receptor expressed in lymphoid tissues, RELT tumor necrosis factor receptor, RELT, TNFRSF19L, TNFRSF
宿主
Mouse IgG2b
免疫原
Mouse myeloma cell line NS0-derived recombinant human RELT/TNFRSF19L
Met1-Ala160 (Arg127Gly, Arg129Gly)
Accession # Q969Z4
克隆号
238104

Scientific Data

Flow Cytometry Detection of RELT/TNFRSF19L antibody in Raji Human Cell Line antibody by Flow Cytometry.View Larger

Detection of RELT/TNFRSF19L in Raji Human Cell Line by Flow Cytometry. Raji human Burkitt's lymphoma cell line was stained with Mouse Anti-Human RELT/TNFRSF19L Monoclonal Antibody (Catalog # MAB1385, filled histogram) or isotype control antibody (Catalog # MAB0041, open histogram), followed by Phycoerythrin-conjugated Anti-Mouse IgG Secondary Antibody (Catalog # F0102B).

Human RELT/TNFRSF19L Antibody Summary

Species Reactivity
Human
Specificity
Detects human RELT/TNFRSF19L in direct ELISAs. In direct ELISAs, no cross-reactivity with recombinant human (rh) 4-1BB, recombinant mouse (rm) 4-1BB, rhBAFF R, rmBAFF R, rhCD27, rmCD27, rhCD30, rmCD30, rhCD40, rmCD40, rhDR3, rmDR3, rhDR6, rhEDAR, rmEDAR, rhFas, rmFas, rrFas, rhGITR, rmGITR, rhHVEM, rhLT beta  R, rmLT beta  R, rhNGF R, rmNGF R, rhOPG, rmOPG, rmOX40, rhRANK, rmRANK, rhTNF RI, rmTNF RI, rhTNF RII, rmTNF RII, rhTRAIL R1, rhTRAIL R2, rhTRAIL R3, rhTRAIL R4, rhTROY, or rmTROY is observed.
Source
Monoclonal Mouse IgG2B Clone # 238104
Purification
Protein A or G purified from hybridoma culture supernatant
Immunogen
Mouse myeloma cell line NS0-derived recombinant human RELT/TNFRSF19L
Met1-Ala160 (Arg127Gly, Arg129Gly)
Accession # Q969Z4
Formulation
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.

Applications

Recommended Concentration
Sample
Flow Cytometry
0.25 µg/106 cells
See below
CyTOF-ready
Ready to be labeled using established conjugation methods. No BSA or other carrier proteins that could interfere with conjugation.
 

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

组成成分
IGG-免疫球蛋白G型抗体
应用
实验应用
Flow Cytometry(0.25 µg/106 cells)
背景
别名
Receptor expressed in lymphoid tissues,RELT tumor necrosis factor receptor,RELT,TNFRSF19L,TNFRSF19LFLJ14993,tumor necrosis factor receptor superfamily member 19L,tumor necrosis factor receptor superfamily, member 19-like,Receptor Expressed in Lymphoid Tissues
背景

Background: RELT/TNFRSF19L

RELT (Receptor Expressed in Lymphoid Tissues) is a type I transmembrane glycoprotein belonging to the tumor necrosis factor receptor superfamily (TNFRSF) and has been designated TNFRSF19-like (TNFRSF19L) (1, 2). It is primarily expressed in hematopoietic tissues and peripheral blood leukocytes. Human RELT cDNA encodes a 430 amino acid (aa) residue precursor protein with a putative 26 aa signal peptide, a 136 aa extracellular domain containing one TNF receptor cysteine-rich domain and one potential N-linked glycosylation site, a 21 aa transmembrane domain and a 247 aa cytoplasmic region containing no death domain. Human RELT shares 85% and 96% aa sequence homology with mouse RELT (Accession # BAC40459) and macaque RELT (Accession # Q9N092), respectively. Among TNFRSF members, the RELT extracellular domain is most closely related to that of TNFRSF19 and OX40. RELT has been shown to exclusively bind the adaptor protein TNF receptor-associated factor 1 (TRAF1). However, it has also been shown to activate the NF-kappa B pathway independently of TRAFs. Immobilized RELT can co‑stimulate T‑cell proliferation in the presence of CD3 signaling, suggesting a potential regulatory role in immune response.

References
Long Name
Receptor Expressed in Lymphoid Tissues
Entrez Gene IDs
84957 (Human); 320100 (Mouse); 101865743 (Cynomolgus Monkey)
Alternate Names
Receptor expressed in lymphoid tissues; RELT tumor necrosis factor receptor; RELT; TNFRSF19L; TNFRSF19LFLJ14993; tumor necrosis factor receptor superfamily member 19L; tumor necrosis factor receptor superfamily, member 19-like
制备和贮存
溶解方法
Reconstitute at 0.5 mg/mL in sterile PBS.
保存方式

Preparation and Storage

Reconstitution
Reconstitute at 0.5 mg/mL in sterile PBS.
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Shipping
The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. *Small pack size (SP) is shipped with polar packs. Upon receipt, store it immediately at -20 to -70 °C
Stability & Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.

参考图片

Detection of RELT/TNFRSF19L in Raji Human Cell Line by Flow Cytometry. Raji human Burkitt's lymphoma cell line was stained with Mouse Anti-Human RELT/TNFRSF19L Monoclonal Antibody (Catalog # MAB1385, filled histogram) or isotype control antibody (Catalog # MAB0041, open histogram), followed by Phycoerythrin-conjugated Anti-Mouse IgG Secondary Antibody (Catalog # F0102B).

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货号:
MAB1385-SP
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