IBMX

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IBMX

品牌： Absin

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参数

分子式：

C₁₀H₁₄N₄O₂

分子量：

222.24

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产品介绍

产品信息

抗原名称

Phosphodiesterase (PDE)

商品描述

IBMX is a potent cyclic nucleotide phosphodiesterase inhibitor; due to this action, the compound increases cyclic AMP and cyclic GMP in tissue and thereby activates CYCLIC NUCLEOTIDE-REGULATED PROTEIN KINASES

分子量

222.24

纯度

99%

可溶性

DMSO : 50 mg/mL (224.98 mM; Need ultrasonic)
Ethanol : ≥ 7.14 mg/mL (32.13 mM)

外观

off-white powder

In vitro(体外研究)

At 100 μM, KMUP-1 (a xanthine derivative) and IBMX are the most effective at inducing tracheal relaxation; the magnitude of the relaxation responses induced by KMUP-1 and IBMX are not significantly different. IBMX (100 μM) activates renal outer medullary K+ (ROMK) channels (n=6, P+ (HK)-fed rats with IBMX (100 μM) for 20 min leads to a significant increase in tubular cAMP content to 1.43±0.35 pg/mm tubule length (n=14) compare with that measured in vehicle-treated controls (0.61±0.13 pg/mm tubule length, n=12, P.

In vivo(体内研究)

IBMX, a non-selective PDE inhibitor significantly decreases the liver glycogen storage (mg/g, IBMX 22±1.5 P0.05) also mc2 does not change plasma glucose (control=141±3 and mc2=145±5). IBMX has the highest efficacy on increasing plasma glucose. Treatments with IBMX and Apocynin significantly decrease cold-induced elevation of right ventricular (RV) systolic pressure (23.5±1.8 and 24.2±0.6 mmHg, respectively) although they do not decrease RV pressure to the warm control levels. IBMX or Apocynin significantly reduces medial layer thickness (19.0±0.9, and 16.9±0.8 μm, respectively) and increases lumen diameter (62.7±4.2, and 59.5±4.3 μm, respectively) of small PAs in cold-exposed rats.

背景

别名

3-异丁基-1-甲基黄嘌呤

分子式

C₁₀H₁₄N₄O₂

CAS号

28822-58-4

制备和贮存

保存方式

Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.

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货号：

abs817348-25mg

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