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MEKK3 (MAPK/ERK Kinase Kinase 3, MEK Kinase 3, MEKK 3, Mitogen-activated Protein Kinase Kinase Kinase 3, MAP3K3, MAPKKK3)
MEKK3 (MAPK/ERK Kinase Kinase 3, MEK Kinase 3, MEKK 3, Mitogen-activated Protein Kinase Kinase Kinase 3, MAP3K3, MAPKKK3)
品牌： Usbiological
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Purified by Protein A affinity chromatography.
反应种属：
Mouse
产品介绍
产品介绍
产品信息
抗原来源
Human
宿主
Mouse
免疫原
Partial recombinant corresponding to aa1-89 from human MAP3K3 (AAH10464) with GST tag. MW of the GST tag alone is 26kD.
产品用途
Suitable for use in ELISA and Western Blot. Other applications not tested.
简单描述
MEKK3 directly regulates the stress-activated protein kinase (SAPK) and extracellular signal-regulated protein kinase (ERK) pathways by activating SEK and MEK1/2 respectively; it does not regulate the p38 pathway. In cotransfection assays, it enhances transcription from a nuclear factor kappa-B (NFKB)-dependent reporter gene, consistent with a role in the SAPK pathway.
氨基酸序列
MNEANVMLPYSGKEEPVLPVAMTLPLPGRGPRCGTAATEGGSSFVNAVVSVLQVGVTLMLYPVSKLETVCALWALSTPALGLGLGCIEK
同种型
IgG2a,k
克隆号
1H3
克隆类别
Monoclonal
纯度
Purified by Protein A affinity chromatography.
形式
Supplied as a liquid in PBS, pH 7.2.
应用
实验应用
E WB
推荐用量
Optimal dilutions to be determined by the researcher.
反应种属
Mouse
交叉反应性
Hu
目标/特异性
Recognizes human MAP3K3.
稀释度
Optimal dilutions to be determined by the researcher.
制备和贮存
保存方式
Storage_Temp:-20°C
Storage_and_Stability:May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
数据库链接
Accession
BC010464, AAH10464.1
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