MMP21 (Matrix Metalloproteinase-21, MMP-21)

Synthetic peptide corresponding to residues in human MMP21.

Suitable for use in Western Blot. Other applications not tested.

The matrix metalloproteinases (MMPs) are a family of peptidase enzymes responsible for the degradation of extracellular matrix components, including collagen, gelatin, fibronectin, laminin and proteoglycan. Transcription of MMP genes is differentially activated by phorbol ester, lipopolysaccharide (LPS) or staphylococcal enterotoxin B (SEB). MMP catalysis requires both calcium and zinc. MMP-21 is 569aa residues in length and consists of a prodomain, catalytic domain, and haemopexin-like domain. It is the human orthologue for XMMP in X. laevis and CyMMP in C. pyrrhogaster. MMP-21 is expressed in various fetal and adult tissues. It a possible target gene of the Wnt pathway, and the expression of this protein is controlled by Pax and Notch transcription factors. MMP-21 may play an important role in embryogenesis, tissue development (particularly in the brain), tumor progression and possibly apoptosis.

IgG

Polyclonal

Purified by immunoaffinity chromatography.

Suitable for use in Western Blot. Other applications not tested.

Western Blot: 1:500-1:1000 Optimal dilutions to be determined by the researcher.

Rabbit

Hu

Recognizes human MMP21.

Q8N119