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产品信息
商品描述
ICCB280 is a potent inducer of C/EBPα. ICCB280 exhibits anti-leukemic properties including terminal differentiation, proliferation arrest, and apoptosis through activation of C/EBPα and affecting its downstream targets (such as C/EBPε, G-CSFR and c-Myc).
分子量
386.4
纯度
98%
可溶性
DMSO : 83.33 mg/mL (215.66 mM; Need ultrasonic)
外观
Yellow solid
In vitro(体外研究)
ICCB280 (0.1-50 μM; 48 h) suppresses the HL-60 cell growth, with an IC50 of 8.6 μM. ICCB280 (10 μM; 2-8 d) increases the C/EBPα expression (mRNA and protein) and modulates its target genes in HL-60 cells. ICCB280 (10 μM; 7 d) induces granulocytic differentiationand and subsequent apoptosis in HL-60 cells.
背景
分子式
C23H18N2O4
CAS号
2041072-41-5
制备和贮存
保存方式
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
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