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产品介绍
产品介绍
产品信息
荧光素标记
Unconjugated
来源纯化
Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Pro353 of human IFIT3 protein.
宿主
Rabbit
商品描述
Product Usage Information
| Application | Dilution |
|---|---|
| Western Blotting | 1:1000 |
| Simple Western™ | 1:10 - 1:50 |
同种型
Rabbit IgG
分子量
60-65
应用
目标/特异性
Specificity/Sensitivity
IFIT3 (E8G5Y) Rabbit mAb recognizes endogenous levels of total IFIT3 protein.
Species Reactivity:
Human
敏感性
Endogenous
背景
背景
IFIT3 (Interferon-induced protein with tetratricopeptide repeats 3; Retinoic acid-induced gene G protein (RIG-G)) is part of the IFIT family of interferon-stimulating genes known for their antiviral properties (1,2). IFIT3 is widely expressed in T cells, B cells, plasmacytoid and myeloid dendritic cells, neurons, and kidney cells (3,4). In response to RNA viral infection, IFIT3 regulates IRF3 activation through interaction with TBK1 and MAVS on the mitochondrion (5). IFIT3 also interacts with IFIT1, leading to inhibitory activity against viral RNA lacking the 2′-O-methylation in the cap structure (6).
1.Yu, M. et al. (1997) Proc Natl Acad Sci U S A 94, 7406-11.
2.Xiao, S. et al. (2006) Proc Natl Acad Sci U S A 103, 16448-53.
3.Fensterl, V. et al. (2008) J Virol 82, 11045-53.
4.Wacher, C. et al. (2007) J Virol 81, 860-71.
5.Liu, X.Y. et al. (2011) J Immunol 187, 2559-68.
6.Johnson, B. et al. (2018) Immunity 48, 487-499.e5.
翻译后修饰
unmodified
制备和贮存
保存方式
Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.
数据库链接
Entrez-Gene ID
3437
UniProt ID
O14879
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