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产品介绍
产品介绍
产品信息
抗原名称
DNA Alkylator_Crosslinker
商品描述
Ifosfamide alkylates and forms DNA crosslinks, thereby preventing DNA strand separation and DNA replication. Ifosfamide is a synthetic analog of the nitrogen mustard cyclophosphamide with antineoplastic activity. This agent is a prodrug that must be activated through hydroxylation by hepatic microsomal enzymes.
分子量
261.09
纯度
99%
可溶性
DMSO : 49 mg/mL (187.7 mM)
Ethanol : 49 mg/mL (187.7 mM)
Water : 48 mg/mL (183.8 mM)
Ethanol : 49 mg/mL (187.7 mM)
Water : 48 mg/mL (183.8 mM)
外观
白色结晶性粉末
In vitro(体外研究)
Ifosfamide is an alkylating chemotherapeutic agent with activity against a wide range of tumors. Ifosfamide is activated by the cytochrome P450 family. Ifosfamide (0-5 mM) suppresses the viability of CYP2B1-expressing C8III-1 cells, while it is cytotoxic to the non-CYP2B1-expressing CrFK cells only at high concentration (5 mM). CYP BM3 mutants activates Ifosfamide, and Ifosfamide shows inhibitory activity against human U2OS cells.
In vivo(体内研究)
Ifosfamide (50 mg/kg, i.p.) treatment before mating increases percentage of post-implantation loss and resorbs fetuses in pregnant rats. Ifosfamide also (50 mg/kg, i.p.) decreases the progesterone in the serum of pregnant rats. However, Ifosfamide causes no obvious difference with the control rats at 25 mg/kg. Ifosfamide (25, 50 mg/kg, i.p.) induces apoptosis and histological changes in the placentas and prenatal rats, most sensitive fetal organs are the brain, liver and kidney.
背景
别名
异环磷酰胺
分子式
C7H15Cl2N2O2P
CAS号
3778-73-2
制备和贮存
保存方式
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
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