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IgG2b Fc (Glu97-Lys335) Protein, Mouse

品牌： UA BIOSCIENCE

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参数

分子量：

纯度：

产品介绍

产品信息

荧光素标记

Unconjugated

氨基酸序列

EPSGPISTINPCPPCKECHKCPAPNLEGGPSVFIFPPNIKDVLMISLTPKVTCVVVDVSEDDPDVQISWFVNNVEVHTAQTQTHREDYNSTIRVVSTLPIQHQDWMSGKEFKCKVNNKDLPSPIERTISKIKGLVRAPQVYILPPPAEQLSRKDVSLTCLVVGFNPGDISVEWTSNGHTEENYKDTAPVLDSDGSYFIYSKLNMKTSKWEKTDSFSCNVRHEGLKNYYLKKTISRSPGL

分子量

32-35 kDa(reducing)

纯度

＞95%, by SDS-PAGE under reducing conditions

内毒素水平

<0.1EU/μg

性状

Lyophilized powder

表达系统

HEK293

缓冲体系

PBS, pH7.4

种属

Mouse

电泳JSON

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背景

Immunoglobulin G (IgG) is the main antibody component in normal human serum, which is produced and secreted by B cells. It is a molecule with a molecular weight of about 150kDa. IgG contains two heavy chains (50kDa) and two light chains (25kDa), which are connected by disulfide bonds. After cleavage by pepsin, IgG is divided into F (ab) s with an antigen binding site and a highly conserved Fc fragment. The Fc fragment has a highly conserved n-glycosylation site. There are 5 subtypes of IgG in mice (IgG1, IgG2a, IgG2b, IgG2c and IgG3) and 4 subtypes in rats (IgG1, IgG2a, IgG2b and IgG2c). Some studies have found that IgG2a is superior to IgG1 in activating complements. IgG2 is mainly used to neutralize antigen or block the binding of receptor ligand. In addition, human EGFR antibody IgG2 can mediate ADCC effect through myeloid cells.

制备和贮存

溶解方法

Reconstitute at less than 1 mg/mL according to the size in ultrapure water after rapid centrifugation .

保存方式

· 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
· 3 months, -20 to -80℃ under sterile conditions after reconstitution.
· 1 week, 2 to 8℃ under sterile conditions after reconstitution.
· Please avoid repeated freeze-thaw cycles.

数据库链接

Accession

P01867-2

参考图片

IgG2b Fc (Glu97-Lys335), Mouse，1μg on SDS-PAGE under reducing and Non-reducing condition. The purity is greater than 95%.

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货号：

UA050006-500ug

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