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产品介绍
产品介绍
产品信息
抗原名称
DENV:0.3 μM, BVDV:0.4 μM, TCRV:0.26 μM, ER α-glucosidase I:0.24 μM
商品描述
IHVR-17028 is a potent broad-spectrum ERα-glucosidase I (α-glucosidase? I) inhibitor with IC50 of 0.24 μM and antiviral activity. IHVR-17028 inhibited BVDV, TCRV and DENV, and EC50 values were 0.4 μM, 0.26 μM and 0.3 μM, respectively. IHVR-17028 can be used to study infectious diseases.
分子量
428.61
纯度
98%
可溶性
DMSO:30 mg/mL (69.99 mM)
In vitro(体外研究)
IHVR-17028 demonstrates potent antiviral activity against bovine viral diarrhea virus (BVDV) (NADL strain), tacaribe virus (TCRV) (11573 strain), and DENV (serotype 2, New Guinea C) with EC50 values of 0.4 μM, 0.26 μM, and 0.3 μM, respectively, in virus yield reduction assays. Furthermore, IHVR-17028 exhibits high cell viability with IC50 values exceeding 500 μM in MDBK, Huh7.5, and BHK cells, as determined by MTT assays.[1]
In vivo(体内研究)
In rats, during pharmacokinetic analysis, IHVR17028 (75 mg/kg, oral gavage) demonstrates a C max value of 0.18 μg/ml. The T max value is 1.56 hours, and after PO administration, the F% value is 12%. The T 1/2 value is 0.88 hours after iv administration[1].
In a mouse model of lethal MARV infection, IHVR-17028 treatment (25-50 mg/kg, oral gavage) one day before virus challenging exhibits significant protection.[1]
背景
分子式
C23H44N2O5
CAS号
1428247-78-2
制备和贮存
保存方式
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
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