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产品介绍
产品介绍
产品信息
抗原名称
Autophagy,PI3Kγ
商品描述
IITZ-01 is a potent autophagy inhibitor, enhancing autophagosome accumulation but inhibiting autophagosomal degradation by impairing lysosomal function.
分子量
482.52
纯度
＞98%
可溶性
DMSO ：100 mg/mL (207.24 mM)
外观
Powder
In vitro(体外研究)
Treatment with IITZ-01 results in the vacuolated appearance of cells due to its specific accumulation in lysosomes. It deacidifies lysosomes and inhibits maturation of lysosomal enzymes leading to lysosomal dysfunction. IITZ-01 enhances autophagosome accumulation but inhibit autophagosomal degradation by impairing lysosomal function, finally resulting in the inhibition of autophagy. It also abolishes mitochondrial membrane potential and triggered apoptosis through the mitochondria-mediated pathway. In in-vitro screening assays, IITZ-01 shows negligible inhibition toward PI3K γ (IC50: 2.62 μM) and no significant inhibition at 10 μM against mTORC1. Immunoblotting experiment has revealed no significant decrease in p-AKT levels in breast cancer cells when treated with IITZ-01. IITZ-01 can trigger apoptosis via disrupting MMP and modulating Bcl-2 and IAP family proteins.
In vivo(体内研究)
IITZ-01 displays potent antitumor action in vivo through autophagy inhibition and apoptosis induction in MDA-MB-231 breast cancer xenograft model.
背景
别名
Autophagy inhibitor；IITZ 01；IITZ01
分子式
C26H23FN8O
CAS号
1807988-47-1
制备和贮存
保存方式
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
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