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IKKB, CT (Inhibitor Of Nuclear Factor kappa B Kinase beta Subunit, I-kappa-B-kinase beta, IkBKB, IKK-beta, IKK-B, I-kappa-B Kinase 2, IKK2, Nuclear Fa


品牌: MyBioSource








反应种属:
Human
实验应用:
Western Blot (WB), Immunohistochemistry (IHC), Immunocytochemistry (ICC)
产品介绍
产品介绍
产品信息
纯化方式
Affinity Purified
Purified by immunoaffinity chromatography.

抗原名称
inhibitor of nuclear factor kappa-B kinase subunit beta isoform 5

免疫原
Synthetic peptide corresponding to aa from human IKKb at C-terminal (KLH).

商品描述
IKKbeta, an IKAPPAB -type protein kinase, is a member of the multimeric IkappaB kinase complex. This complex, often consisting of IKKalpha/IKKbeta heterodimers plus regulatory IKKgamma subunits, phosphorylates IkappaB proteins, marking them for destruction and thereby allowing activation of NFkappaB and downstream nuclear genes. The constitutively expressed IKKbeta protein contains an N-terminal kinase domain, a central leucine zipper motif, and a C-terminal helix-loop-helix motif. In knockout studies, IKKbeta (-/-) mice died between embryonic day 12.5 and 14 due to extensive liver damage from apoptosis; however, they were rescued by inactivation of the tumor necrosis factor receptor 1 gene. IKKbeta has been implicated in the pathogenesis of insulin resistance in obesity and type II diabetes mellitus.

形式
Supplied as a liquid in PBS, 0.02% sodium azide.

产品类型
Polyclonal

应用
实验应用
Western Blot (WB), Immunohistochemistry (IHC), Immunocytochemistry (ICC)

反应种属
Human

背景
别名
Anti -IKKB, CT (Inhibitor Of Nuclear Factor kappa B Kinase beta Subunit, I-kappa-B-kinase beta, IkBKB, IKK-beta, IKK-B, I-kappa-B Kinase 2, IKK2, Nuclear Factor NF-kappa-B Inhibitor Kinase beta, NFKBIKB, IKBKB)

制备和贮存
保存方式
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
数据库链接
NCBI
3551

UniProt ID
O14920
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