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IL-12 Protein,Mouse
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对比
咨询P40: 35.8 kDa (Reducing)
P35: 22.5 kDa (Reducing)
p40: Met23-Ser335; p35: Arg23-Ala215, with C-terminal His Tag
P40: 35.8 kDa (Reducing)
P35: 22.5 kDa (Reducing)
PBS, pH7.4.
2μg (R: reducing condition, N: non-reducing condition).
IL-12 is involved in the differentiation of naive T cells into Th1 cells. It is known as a T cell-stimulating factor, which can stimulate the growth and function of T cells. It stimulates the production of interferon-gamma (IFN-γ) and tumor necrosis factor-alpha (TNF-α) from T cells and natural killer (NK) cells, and reduces IL-4 mediated suppression of IFN-γ. T cells that produce IL-12 have a coreceptor, CD30, which is associated with IL-12 activity. IL-12 plays an important role in the activities of natural killer cells and T lymphocytes. IL-12 mediates enhancement of the cytotoxic activity of NK cells and CD8+ cytotoxic T lymphocytes.
Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.
· 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
· 3 months, -20 to -80℃ under sterile conditions after reconstitution.
· 1 week, 2 to 8℃ under sterile conditions after reconstitution.
· Please avoid repeated freeze-thaw cycles.
1. Airoldi, I. et al. (2000) Journal of Immunology 165:6880.
2. Wolf, S.F. et al. (1991) Journal of Immunology 146:3074.
3. Gearing, D. et al. (1991) Cell 66:9.
4. Merberg, D. et al. (1992) Immunology Today 13:78.
5. Gubler, U. et al. (1991) Proc. Natl. Acad. Sci. 88:4143.
参考图片
2μg (R: reducing condition, N: non-reducing condition).
>95% as determined by RP-HPLC.
Measured by its ability to enhance IFN-gamma secretion in NK-92 human natural killer lymphoma cells. The EC50 for this effect is less than 0.6ng/ml.