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IL-34 Protein, Human
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咨询30-38 kDa (Reducing)
Asn21-Pro242, with C-terminal His Tag
30-38 kDa (Reducing)
20mM Tris, 300mM NaCl, pH8.0
2μg (R: reducing condition, N: non-reducing condition).
Interleukin-34 (IL-34) is a cytokine that was discovered in 2008 through functional screening of the extracellular proteome. It shares many functional similarities with colony-stimulating factor 1 (CSF-1), as both can bind to the CSF-1 receptor (CSF-1R) and regulate the differentiation and function of monocytes and macrophages. IL-34 is expressed in various tissues, including the brain, skin, and immune organs, and plays important roles in immune regulation, tissue homeostasis, and inflammation.
The IL-34/CSF-1R axis is a potential therapeutic target for various diseases, including cancer, inflammatory diseases, and autoimmune disorders. Also, IL-34 can serve as a biomarker for certain conditions. For instance, its expression levels in tissues or body fluids may indicate the presence or severity of diseases such as liver fibrosis and diabetic complications.
Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.
·12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
·3 months, -20 to -80℃ under sterile conditions after reconstitution.
·1 week, 2 to 8℃ under sterile conditions after reconstitution.
·Please avoid repeated freeze-thaw cycles.
Science. 2008 May 9;320(5877):807-11.
Nat Immunol. 2012 Jun 24;13(8):753-60.