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IL-6 Protein, Mouse
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对比
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Phe25-Thr211
22kDa
1x PBS, pH 7.4
Interleukin-6 (IL-6) is a pro-inflammatory cytokine that also has an important role in immunity. Mouse IL-6 appears to be directly involved in the responses that occur after infection and injury and may prove to be as important as IL-1 in regulating the acute phase response. Mouse IL-6 is reported to be produced by fibroblasts, activated T cells, activated monocytes or macrophages, and endothelial cells. It acts upon a variety of cells, including fibroblasts, myeloid progenitor cells, T cells, B cells and hepatocytes. IL-6 has a wide variety of biological functions: it plays an essential role in the final differentiation of B-cells into Ig-secreting cells, it induces myeloma and plasmacytoma growth, nerve cells differentiation in hepatocytes, and acute phase reactants.
Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.
· 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
· 3 months, -20 to -80℃ under sterile conditions after reconstitution.
· 1 week, 2 to 8℃ under sterile conditions after reconstitution.
· Please avoid repeated freeze-thaw cycles.
1. Cold Spring Harb Perspect Biol. 2014 Sep 4;6(10):a016295.
2. Cold Spring Harb Perspect Biol. 2018 Aug 1;10(8):a028456.
3. Biochem J. 2003 Aug 15;374(Pt 1):1-20.
参考图片
Measured in a cell proliferation assay using Murine B9 cells, the EC50 for this effect is less than 5ng/ml.