IL-10 (D13A11) Rabbit mAb

Interleukin-10 (IL-10) is an anti-inflammatory cytokine that is produced by T cells, NK cells, and macrophages (1,2). IL-10 initiates signal transduction by binding to a cell surface receptor complex consisting of IL-10 RI and IL-10 RII (1), leading to the activation of Jak1 and Tyk2 and phosphorylation of Stat3 (1,3). The anti-inflammatory activity of IL-10 is due to its ability to block signaling through other cytokine receptors, notably IFN-γ receptor, by upregulating expression of SOCS1 (1,3). In addition, IL-10 promotes T cell tolerance by inhibiting tyrosine phosphorylation of CD28 (4,5). IL-10 is an important negative regulator of the immune response, which allows for maintenance of pregnancy (1). In contrast, increased IL-10 levels contribute to persistent Leishmania major infections (6). 1.Pestka, S. et al. (2004) Immunol Rev 202, 8-32. 2.Akuffo, H. et al. (1999) Clin Exp Immunol 117, 529-34. 3.O'Shea, J.J. and Murray, P.J. (2008) Immunity 28, 477-87. 4.Akdis, C.A. and Blaser, K. (2001) Immunology 103, 131-6. 5.Akdis, C.A. et al. (2000) FASEB J 14, 1666-8. 6.Von Stebut, E. Eur J Dermatol 17, 115-22.