Mouse IL-17 Quantikine ELISA Kit

1/2

Mouse IL-17 Quantikine ELISA Kit

品牌： R&D Systems

下载产品说明书

下载SDS

用小程序，查商品更便捷

对比

咨询

参数

反应种属：

产品介绍

产品信息

商品描述

The Quantikine Mouse IL-17 Immunoassay is a 4.5 hour solid phase ELISA designed to measure mouse IL-17 in cell culture supernates, serum, and plasma. It contains E. coli-expressed recombinant mouse IL-17 and antibodies raised against the recombinant factor. This immunoassay has been shown to quantitate recombinant mouse IL-17 accurately. Results obtained using natural mouse IL-17 showed linear curves that were parallel to the standard curves obtained using the recombinant Quantikine kit standards. These results indicate that this kit can be used to determine relative mass values for natural mouse IL-17.

生物活性

Cross-reactivity observed with 1 or more available related molecules.< 50% cross-species reactivity observed with species tested.

应用

反应种属

Mouse

目标/特异性

Natural and recombinant mouse IL-17

检测类型

Solid Phase Sandwich ELISA

样本类型以及上样量

Cell Culture Supernates (50 uL), Serum (50 uL), EDTA Plasma (50 uL), Heparin Plasma (50 uL)

背景

别名

CTLA8,CTLA-8,CTLA8cytotoxic T-lymphocyte-associated serine esterase 8,Cytotoxic T-lymphocyte-associated antigen 8,IL17,IL-17,IL17A,IL-17A,IL-17Acytotoxic T-lymphocyte-associated protein 8,IL-17CTLA-8,IL17interleukin-17A,interleukin 17 (cytotoxic T-lymphocyte-associated serine esterase 8),interleukin 17A,Interleukin 17

背景

The IL-17 family is comprised of at least six proinflammatory cytokines that share a conserved cysteine-knot structure but diverge at the N-terminus. IL-17 family members are glycoproteins secreted as dimers that induce local cytokine production and recruit granulocytes to sites of inflammation. IL-17 is induced by IL-15 and IL-23, mainly in activated CD4+ T cells distinct from Th1 or Th2 cells. IL-17F is the most homologous to IL-17, but is induced only by IL-23 in activated monocytes. IL-17B binds the IL-17B receptor, but not the IL-17 receptor; it is most homologous with IL-17D, which is expressed by resting CD4+ T cells and CD19+ B cells. IL-17E is mainly produced by Th2 cells and recruits eosinophils to lung tissue. IL-17C has a very restricted expression pattern but has been detected in adult prostate and fetal kidney libraries.

文献

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

Toll-Like Receptor 4 Signaling Pathway Mediates Inhalant Organic Dust-Induced Bone Loss
PLoS ONE, 2016;11(8):e0158735.
Species: Mouse
Sample Type: Serum

CF Lung Infection and Inflammation: IL-17 Pathophysiology and Therapeutic Intervention
Authors: Daniel Hsu
Infect Immun, 2016;0(0):.
Species: Mouse
Sample Type: BALF

Increased mitochondrial arginine metabolism supports bioenergetics in asthma
J Clin Invest, 2016;0(0):.
Species: Mouse
Sample Type: BAL

Critical role for IL-18 in spontaneous lung inflammation caused by autophagy deficiency.
Authors: Abdel Fattah E, Bhattacharya A, Herron A, Safdar Z, Eissa N
J Immunol, 2015;194(11):5407-16.
Species: Mouse
Sample Type: BALF

Thalidomide inhibits alternative activation of macrophages in vivo and in vitro: a potential mechanism of anti-asthmatic effect of thalidomide.
Authors: Lee, Hyun Seu, Kwon, Hyouk-So, Park, Da-Eun, Woo, Yeon Duk, Kim, Hye Youn, Kim, Hang-Rae, Cho, Sang-Heo, Min, Kyung-Up, Kang, Hye-Ryun, Chang, Yoon-Seo
PLoS ONE, 2015;10(4):e0123094.
Species: Mouse
Sample Type: BALF

IL-1 signaling modulates activation of STAT transcription factors to antagonize retinoic acid signaling and control the TH17 cell-iTreg cell balance.
Authors: Basu R, Whitley S, Bhaumik S, Zindl C, Schoeb T, Benveniste E, Pear W, Hatton R, Weaver C
Nat Immunol, 2015;16(3):286-95.
Species: Mouse
Sample Type: Cell Culture Supernates

Sirt2 suppresses inflammatory responses in collagen-induced arthritis.
Authors: Lin J, Sun B, Jiang C, Hong H, Zheng Y
Biochem Biophys Res Commun, 2013;441(4):897-903.
Species: Mouse
Sample Type: Serum

AMPKalpha1 deficiency amplifies proinflammatory myeloid APC activity and CD40 signaling.
Authors: Carroll K, Viollet B, Suttles J
J Leukoc Biol, 2013;94(6):1113-21.
Species: Mouse
Sample Type: cell culture supernate

Steady-state neutrophil homeostasis is dependent on TLR4/TRIF signaling.
Authors: Bugl S, Wirths S, Radsak M, Schild H, Stein P, Andre M, Muller M, Malenke E, Wiesner T, Marklin M, Frick J, Handgretinger R, Rammensee H, Kanz L, Kopp H
Blood, 2013;121(5):723-33.
Species: Mouse
Sample Type: Plasma

Staphylococcus aureus sarA regulates inflammation and colonization during central nervous system biofilm formation.
Authors: Snowden J, Beaver M, Beenken K, Smeltzer M, Horswill A, Kielian T
PLoS ONE, 2013;8(12):e84089.
Species: Mouse
Sample Type: Homogenized Tissue

The Receptor Slamf1 on the Surface of Myeloid Lineage Cells Controls Susceptibility to Infection by Trypanosoma cruzi.
Authors: Calderon J, Maganto-Garcia E, Punzon C, Carrion J, Terhorst C, Fresno M
PLoS Pathog., 2012;8(7):e1002799.
Species: Mouse
Sample Type: Serum

Salmonella enterica induces joint inflammation and expression of interleukin-17 in draining lymph nodes early after onset of enterocolitis in mice.
Authors: Noto Llana M, Sarnacki SH, Vazquez MV, Gartner AS, Giacomodonato MN, Cerquetti MC
Infect. Immun., 2012;80(6):2231-9.
Species: Mouse
Sample Type: Tissue Homogenates

Dual functions of prostaglandin D2 in murine contact hypersensitivity via DP and CRTH2.
Authors: Yamamoto Y, Otani S, Hirai H, Nagata K, Aritake K, Urade Y, Narumiya S, Yokozeki H, Nakamura M, Satoh T
Am. J. Pathol., 2012;179(1):302-14.
Species: Mouse
Sample Type: Tissue Homogenates

Elevating body temperature enhances hematopoiesis and neutrophil recovery after total body irradiation in an IL-1-, IL-17-, and G-CSF-dependent manner.
Blood, 2012;120(13):2600-9.
Species: Mouse
Sample Type: tissue lysates

The Role of IL-15 in Activating STAT5 and Fine-Tuning IL-17A Production in CD4 T Lymphocytes.
Authors: Pandiyan P, Yang X, Saravanamuthu S, Zheng L, Ishihara S
J. Immunol., 2012;189(9):4237-46.
Species: Mouse
Sample Type: Cell Culture Supernates

IL-33-responsive lineage- CD25+ CD44(hi) lymphoid cells mediate innate type 2 immunity and allergic inflammation in the lungs.
Authors: Bartemes KR, Iijima K, Kobayashi T, Kephart GM, McKenzie AN, Kita H
J. Immunol., 2011;188(3):1503-13.
Species: Mouse
Sample Type: BALF

Serotonin activates dendritic cell function in the context of gut inflammation.
Authors: Li N, Ghia JE, Wang H, McClemens J, Cote F, Suehiro Y, Mallet J, Khan WI
Am. J. Pathol., 2011;178(2):662-71.
Species: Mouse
Sample Type: Cell Culture Supernates

IL-17-producing invariant NKT cells in lymphoid organs are recent thymic emigrants identified by neuropilin-1 expression.
Authors: Milpied P, Massot B, Renand A, Diem S, Herbelin A, Leite-de-Moraes M, Rubio MT, Hermine O
Blood, 2011;118(11):2993-3002.
Species: Mouse
Sample Type: Cell Culture Supernates

The TLR7 ligand 9-benzyl-2-butoxy-8-hydroxy adenine inhibits IL-17 response by eliciting IL-10 and IL-10-inducing cytokines.
Authors: Vultaggio A, Nencini F, Pratesi S, Maggi L, Guarna A, Annunziato F, Romagnani S, Parronchi P, Maggi E
J. Immunol., 2011;186(8):4707-15.
Species: Mouse
Sample Type: Serum

ChemR23 dampens lung inflammation and enhances anti-viral immunity in a mouse model of acute viral pneumonia.
Authors: Bondue B, Vosters O, de Nadai P, Glineur S, De Henau O, Luangsay S, Van Gool F, Communi D, De Vuyst P, Desmecht D, Parmentier M
PLoS Pathog., 2011;7(11):e1002358.
Species: Mouse
Sample Type: Tissue Homogenates

Reciprocal expression of IL-25 and IL-17A is important for allergic airways hyperreactivity.
Authors: Barlow JL, Flynn RJ, Ballantyne SJ, McKenzie AN
Clin. Exp. Allergy, 2011;41(10):1447-55.
Species: Mouse
Sample Type: BALF

Role of IL-17A in neutrophil recruitment and hepatic injury after warm ischemia-reperfusion mice.
Authors: Kono H, Fujii H, Ogiku M, Hosomura N, Amemiya H, Tsuchiya M, Hara M
J. Immunol., 2011;187(9):4818-25.
Species: Mouse
Sample Type: Serum

IL-23-Mediated Epidermal Hyperplasia Is Dependent on IL-6.
Authors: Lindroos J, Svensson L, Norsgaard H
J. Invest. Dermatol., 2011;131(5):1110-8.
Species: Mouse
Sample Type: Tissue Homogenates

Co-adjuvant effects of retinoic acid and IL-15 induce inflammatory immunity to dietary antigens.
Authors: DePaolo RW, Abadie V, Tang F
Nature, 2011;471(7337):220-4.
Species: Mouse
Sample Type: Cell Culture Supernates

Prostaglandin I2-IP signaling promotes Th1 differentiation in a mouse model of contact hypersensitivity.
Authors: Nakajima S, Honda T, Sakata D, Egawa G, Tanizaki H, Otsuka A, Moniaga CS, Watanabe T, Miyachi Y, Narumiya S, Kabashima K
J. Immunol., 2010;184(10):5595-603.
Species: Mouse
Sample Type: Cell Culture Supernates

Morphine disrupts interleukin-23 (IL-23)/IL-17-mediated pulmonary mucosal host defense against Streptococcus pneumoniae infection.
Authors: Ma J, Wang J, Wan J, Charboneau R, Chang Y, Barke RA, Roy S
Infect. Immun., 2010;78(2):830-7.
Species: Mouse
Sample Type: BALF

Critical role of the disintegrin metalloprotease ADAM17 for intestinal inflammation and regeneration in mice.
Authors: Chalaris A, Adam N, Sina C, Rosenstiel P, Lehmann-Koch J, Schirmacher P, Hartmann D, Cichy J, Gavrilova O, Schreiber S, Jostock T, Matthews V, Hasler R, Becker C, Neurath MF, Reiss K, Saftig P, Scheller J, Rose-John S
J. Exp. Med., 2010;207(8):1617-24.
Species: Mouse
Sample Type: Cell Culture Supernates

TLR4 activation is required for IL-17-induced multiple tissue inflammation and wasting in mice.
Authors: Tang H, Pang S, Wang M
J. Immunol., 2010;185(4):2563-9.
Species: Mouse
Sample Type: Tissue Homogenates

Enhanced production of IL-17A during zymosan-induced peritonitis in obese mice.
Authors: Pini M, Fantuzzi G
J. Leukoc. Biol., 2010;87(1):51-8.
Species: Mouse
Sample Type: Peritoneal Lavage

IL-23 and IL-17A, but not IL-12 and IL-22, are required for optimal skin host defense against Candida albicans.
Authors: Kagami S, Rizzo HL, Kurtz SE
J. Immunol., 2010;185(9):5453-62.
Species: Mouse
Sample Type: Tissue Homogenates

Cell adhesion molecules regulate fibrotic process via Th1/Th2/Th17 cell balance in a bleomycin-induced scleroderma model.
Authors: Yoshizaki A, Yanaba K, Iwata Y
J. Immunol., 2010;185(4):2502-15.
Species: Mouse
Sample Type: Serum

Antigen-specific Th9 cells exhibit uniqueness in their kinetics of cytokine production and short retention at the inflammatory site.
Authors: Tan C, Aziz MK, Lovaas JD, Vistica BP, Shi G, Wawrousek EF, Gery I
J. Immunol., 2010;185(11):6795-801.
Species: Mouse
Sample Type: Cell Culture Supernates

Prostaglandin E2 regulates Th17 cell differentiation and function through cyclic AMP and EP2/EP4 receptor signaling.
Authors: Boniface K, Bak-Jensen KS, Li Y, Blumenschein WM, McGeachy MJ, McClanahan TK, McKenzie BS, Kastelein RA, Cua DJ, de Waal Malefyt R
J. Exp. Med., 2009;206(3):535-48.
Species: Mouse
Sample Type: Cell Culture Supernates

Phosphodiesterase 7A inhibitor ASB16165 suppresses proliferation and cytokine production of NKT cells.
Authors: Goto M, Murakawa M, Kadoshima-Yamaoka K, Tanaka Y, Inoue H, Murafuji H, Hayashi Y, Miura K, Nakatsuka T, Nagahira K, Chamoto K, Fukuda Y, Nishimura T
Cell. Immunol., 2009;258(2):147-51.
Species: Mouse
Sample Type: Cell Culture Supernates

Differential IL-23 requirement for IL-22 and IL-17A production during innate immunity against Salmonella enterica serovar Enteritidis.
Authors: Siegemund S, Schutze N, Schulz S, Wolk K, Nasilowska K, Straubinger RK, Sabat R, Alber G
Int. Immunol., 2009;21(5):555-65.
Species: Mouse
Sample Type: Serum

TLR2 deficiency leads to increased Th17 infiltrates in experimental brain abscesses.
Authors: Nichols JR, Aldrich AL, Mariani MM, Vidlak D, Esen N, Kielian T
J. Immunol., 2009;182(11):7119-30.
Species: Mouse
Sample Type: Tissue Homogenates

Mouse models of asthma: a comparison between C57BL/6 and BALB/c strains regarding bronchial responsiveness, inflammation, and cytokine production.
Authors: Gueders MM, Paulissen G, Crahay C, Quesada-Calvo F, Hacha J, Van Hove C, Tournoy K, Louis R, Foidart JM, Noel A, Cataldo DD
Inflamm. Res., 2009;58(12):845-54.
Species: Mouse
Sample Type: BALF

Exaggerated IL-17 response to epicutaneous sensitization mediates airway inflammation in the absence of IL-4 and IL-13.
Authors: He R, Kim HY, Yoon J, Oyoshi MK, MacGinnitie A, Goya S, Freyschmidt EJ, Bryce P, McKenzie AN, Umetsu DT, Oettgen HC, Geha RS
J. Allergy Clin. Immunol., 2009;124(4):761-70.e1.
Species: Mouse
Sample Type: Serum

IL-17 receptor signaling is required to control polymicrobial sepsis.
Authors: Freitas A, Alves-Filho JC, Victoni T, Secher T, Lemos HP, Sonego F, Cunha FQ, Ryffel B
J. Immunol., 2009;182(12):7846-54.
Species: Mouse
Sample Type: Peritoneal Exudate

A MyD88-dependent early IL-17 production protects mice against airway infection with the obligate intracellular pathogen Chlamydia muridarum.
Authors: Zhang X, Gao L, Lei L, Zhong Y, Dube P, Berton MT, Arulanandam B, Zhang J, Zhong G
J. Immunol., 2009;183(2):1291-300.
Species: Mouse
Sample Type: BALF

Inhibition of monocyte-derived inflammatory cytokines by IL-25 occurs via p38 Map kinase-dependent induction of Socs-3.
Authors: Caruso R, Stolfi C, Sarra M, Rizzo A, Fantini MC, Pallone F, MacDonald TT, Monteleone G
Blood, 2009;113(15):3512-9.
Species: Mouse
Sample Type: Serum

Adverse functions of IL-17A in experimental sepsis.
Authors: Flierl MA, Rittirsch D, Gao H, Hoesel LM, Nadeau BA, Day DE, Zetoune FS, Sarma JV, Huber-Lang MS, Ferrara JL, Ward PA
FASEB J., 2008;22(7):2198-205.
Species: Mouse
Sample Type: Plasma

Engagement of the type I interferon receptor on dendritic cells inhibits T helper 17 cell development: role of intracellular osteopontin.
Authors: Shinohara ML, Kim JH, Garcia VA, Cantor H
Immunity, 2008;29(1):68-78.
Species: Mouse
Sample Type: Cell Culture Supernates

An L-selectin ligand distinct from P-selectin glycoprotein ligand-1 is expressed on endothelial cells and promotes neutrophil rolling in inflammation.
Authors: Shigeta A, Matsumoto M, Tedder TF, Lowe JB, Miyasaka M, Hirata T
Blood, 2008;112(13):4915-23.
Species: Mouse
Sample Type: Serum

TLR-2 and IL-17A in chitin-induced macrophage activation and acute inflammation.
Authors: Da Silva CA, Hartl D, Liu W, Lee CG, Elias JA
J. Immunol., 2008;181(6):4279-86.
Species: Mouse
Sample Type: BALF

T-cell-expressed proprotein convertase furin is essential for maintenance of peripheral immune tolerance.
Authors: Pesu M, Watford WT, Wei L, Xu L, Fuss I, Strober W, Andersson J, Shevach EM, Quezado M, Bouladoux N, Roebroek A, Belkaid Y, Creemers J, O'Shea JJ
Nature, 2008;455(7210):246-50.
Species: Mouse
Sample Type: Cell Culture Supernates

Resveratrol inhibits high glucose-induced PI3K/Akt/ERK-dependent interleukin-17 expression in primary mouse cardiac fibroblasts.
Authors: Venkatachalam K, Mummidi S, Cortez DM, Prabhu SD, Valente AJ, Chandrasekar B
Am. J. Physiol. Heart Circ. Physiol., 2008;294(5):H2078-87.
Species: Mouse
Sample Type: Cell Culture Supernates

Crucial role of the interleukin-6/interleukin-17 cytokine axis in the induction of arthritis by glucose-6-phosphate isomerase.
Authors: Iwanami K, Matsumoto I, Tanaka-Watanabe Y, Inoue A, Mihara M, Ohsugi Y, Mamura M, Goto D, Ito S, Tsutsumi A, Kishimoto T, Sumida T
Arthritis Rheum., 2008;58(3):754-63.
Species: Mouse
Sample Type: Cell Culture Supernates

Novel immunomodulatory properties of berbamine through selective down-regulation of STAT4 and action of IFN-gamma in experimental autoimmune encephalomyelitis.
Authors: Ren Y, Lu L, Guo TB, Qiu J, Yang Y, Liu A, Zhang JZ
J. Immunol., 2008;181(2):1491-8.
Species: Mouse
Sample Type: Cell Culture Supernates

IL-21 is produced by Th17 cells and drives IL-17 production in a STAT3-dependent manner.
Authors: Wei L, Laurence A, Elias KM, O'Shea JJ
J. Biol. Chem., 2007;282(48):34605-10.
Species: Mouse
Sample Type: Cell Culture Supernates

Functional relevance of the IL-23-IL-17 axis in lungs in vivo.
Authors: Ivanov S, Bozinovski S, Bossios A, Valadi H, Vlahos R, Malmhall C, Sjostrand M, Kolls JK, Anderson GP, Linden A
Am. J. Respir. Cell Mol. Biol., 2007;36(4):442-51.
Species: Mouse
Sample Type: BALF

Differential glycosylation of TH1, TH2 and TH-17 effector cells selectively regulates susceptibility to cell death.
Authors: Toscano MA, Bianco GA, Ilarregui JM, Croci DO, Correale J, Hernandez JD, Zwirner NW, Poirier F, Riley EM, Baum LG, Rabinovich GA
Nat. Immunol., 2007;8(8):825-34.
Species: Mouse
Sample Type: Cell Culture Supernates

TGF-beta and IL-6 drive the production of IL-17 and IL-10 by T cells and restrain T(H)-17 cell-mediated pathology.
Authors: McGeachy MJ, Bak-Jensen KS, Chen Y, Tato CM, Blumenschein W, McClanahan T, Cua DJ
Nat. Immunol., 2007;8(12):1390-7.
Species: Mouse
Sample Type: Cell Culture Supernates

T-bet inhibits both TH2 cell-mediated eosinophil recruitment and TH17 cell-mediated neutrophil recruitment into the airways.
Authors: Fujiwara M, Hirose K, Kagami S, Takatori H, Wakashin H, Tamachi T, Watanabe N, Saito Y, Iwamoto I, Nakajima H
J. Allergy Clin. Immunol., 2007;119(3):662-70.
Species: Mouse
Sample Type: BALF

The development of inflammatory T(H)-17 cells requires interferon-regulatory factor 4.
Authors: Brustle A, Heink S, Huber M, Rosenplanter C, Stadelmann C, Yu P, Arpaia E, Mak TW, Kamradt T, Lohoff M
Nat. Immunol., 2007;8(9):958-66.
Species: Mouse
Sample Type: Cell Culture Supernates

Intercellular adhesion molecule-1 expression is required on multiple cell types for the development of experimental autoimmune encephalomyelitis.
Authors: Bullard DC, Hu X, Schoeb TR, Collins RG, Beaudet AL, Barnum SR
J. Immunol., 2007;178(2):851-7.
Species: Mouse
Sample Type: Cell Culture Supernates

IL-17 receptor signaling influences virus-induced corneal inflammation.
Authors: Molesworth-Kenyon SJ, Yin R, Oakes JE, Lausch RN
J. Leukoc. Biol., 2007;83(2):401-8.
Species: Mouse
Sample Type: Cell Culture Supernates

A novel polysaccharide of black soybean promotes myelopoiesis and reconstitutes bone marrow after 5-flurouracil- and irradiation-induced myelosuppression.
Authors: Liao HF, Chen YJ, Yang YC
Life Sci., 2005;77(4):400-13.
Species: Mouse
Sample Type: Cell Culture Supernates

Matrix metalloproteinase-8 deficiency promotes granulocytic allergen-induced airway inflammation.
Authors: Gueders MM, Balbin M, Rocks N, Foidart JM, Gosset P, Louis R, Shapiro S, Lopez-Otin C, Noel A, Cataldo DD
J. Immunol., 2005;175(4):2589-97.
Species: Mouse
Sample Type: BALF

Endogenous IL-17 as a mediator of neutrophil recruitment caused by endotoxin exposure in mouse airways.
Authors: Miyamoto M, Prause O, Sjostrand M, Laan M, Lotvall J, Linden A
J. Immunol., 2003;170(9):4665-72.
Species: Mouse
Sample Type: Cell Culture Supernates

IL-17, produced by lymphocytes and neutrophils, is necessary for lipopolysaccharide-induced airway neutrophilia: IL-15 as a possible trigger.
Authors: Ferretti S, Bonneau O, Dubois GR, Jones CE, Trifilieff A
J. Immunol., 2003;170(4):2106-12.
Species: Mouse
Sample Type: BALF

Requirement of interleukin 17 receptor signaling for lung CXC chemokine and granulocyte colony-stimulating factor expression, neutrophil recruitment, and host defense.
Authors: Ye P, Rodriguez FH, Kanaly S, Stocking KL, Schurr J, Schwarzenberger P, Oliver P, Huang W, Zhang P, Zhang J, Shellito JE, Bagby GJ, Nelson S, Charrier K, Peschon JJ, Kolls JK
J. Exp. Med., 2001;194(4):519-27.
Species: Mouse
Sample Type: BALF

IL-1-independent role of IL-17 in synovial inflammation and joint destruction during collagen-induced arthritis.
Authors: Lubberts E, Joosten LA, Oppers B, van den Bersselaar L, Coenen-de Roo CJ, Kolls JK, Schwarzenberger P, van de Loo FA, van den Berg WB
J. Immunol., 2001;167(2):1004-13.
Species: Mouse
Sample Type: Cell Culture Supernates

声明：本官网所有报价均为常温或者蓝冰运输价格，如有产品需要干冰运输，需另外加收干冰运输费。

货号：

M1700

一键复制

询价

1KIT

1PACK

1Kit

选择数量

当前规格1件起购

配送至

预计2-3周送达，快递: 免运费，若需干冰额外收费

询价大包装询价