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InVivoMAb anti-mouse IL-27 p28
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InVivoMAb anti-mouse IL-27 p28

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品牌: BioXcell
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反应种属:
mouse
来源宿主:
产品介绍
产品介绍
产品信息
宿主
克隆号
MM27.7B1
克隆类别
单抗

Product Details

The MM27.7B1 monoclonal antibody reacts with the p28 subunit of mouse IL-27, a member of the IL-6/IL-12 cytokine family. IL-27 is a heterodimeric cytokine composed the EBI3 (Epstein-Barr virus induced gene 3) protein and the p28 subunit, also known as IL-30. Myeloid cells including macrophages, inflammatory monocytes, microglia, and dendritic cells are the dominant cellular sources of IL-27. These cells secrete IL-27 in response to TLR ligands and inflammatory cytokines. IL-27 p28 signals through IL-27 receptors (IL-27R) which are highly expressed by NK cells and activated T cells and to a lesser extent on B cells, naïve T cells, and others. IL-27 signaling has been shown to have both pro-inflammatory and anti-inflammatory effects. Signaling through IL-27R promotes Th1 polarization and IFNγ production but also suppresses the differentiation and proliferation of Th2 and Th17 cells and induces the expression of IL-10. The MM27.7B1 clone has been shown to neutralize the bioactivity of mouse IL-27 in vivo and in vitro and reported to also bind and inhibit human IL-27.

Specifications

Isotype Mouse IgG2a, κ
Recommended Isotype Control(s)InVivoMAb mouse IgG2a isotype control, unknown specificity
Recommended Dilution BufferInVivoPure pH 7.0 Dilution Buffer
Conjugation This product is unconjugated. Conjugation is available via our Antibody Conjugation Services.
Immunogen Mouse IL-27
Reported Applicationsin vivo IL-27 p28 neutralization
in vitro IL-27 p28 neutralization
Flow cytometry
Formulation PBS, pH 7.0
Contains no stabilizers or preservatives
Endotoxin <2EU/mg (<0.002EU/μg)
Determined by LAL gel clotting assay
Purity >95%
Determined by SDS-PAGE
Sterility 0.2 µm filtration
Production Purified from cell culture supernatant in an animal-free facility
Purification Protein A
RRIDAB_2819053
Molecular Weight 150 kDa
Storage The antibody solution should be stored at the stock concentration at 4°C. Do not freeze.
组成成分
白细胞介素蛋白抗体,磷酸盐缓冲液
应用
反应种属
mouse
背景
研究领域
Cancer Biology, Cytokine and Chemokine, Immunology, Innate Immunity, Tumor Antigens
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货号:
BE0326-1MG
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