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产品信息
克隆号
ALF-161
克隆类别
单抗
Product Details
The ALF-161 monoclonal antibody reacts with precursor, secreted and membrane-associated forms of mouse IL-1α (interleukin 1 alpha) also known as lymphocyte activating factor (LAF), and mononuclear cell factor (MCF). IL-1α is a 17 kDa pro-inflammatory cytokine produced by a variety of cells, including macrophages, dendritic cells, T and B lymphocytes. IL-1α exerts a wide range of immune and inflammatory responses on a many cell types including lymphocytes, epithelial cells and fibroblasts. IL-1 is made up of IL-1α and IL-1β which are the products of distinct genes, but which are recognized by two distinct IL-1 receptors. The IL-1 receptor type I, a 80 kDa transmembrane protein with demonstrated IL-1 signaling function and the IL-1 receptor type II, a 68 kDa membrane protein with a relatively short cytoplasmic tail. The type II receptor acts as a decoy target for IL-1, inhibiting IL-1 activities by preventing the binding of IL-1 to the type I receptor. The ALF-161 antibody has been shown to neutralize the bioactivity of natural or recombinant IL-1α.Specifications
| Isotype | Armenian hamster IgG |
|---|---|
| Recommended Isotype Control(s) | InVivoMAb polyclonal Armenian hamster IgG |
| Recommended Dilution Buffer | InVivoPure pH 7.0 Dilution Buffer |
| Conjugation | This product is unconjugated. Conjugation is available via our Antibody Conjugation Services. |
| Immunogen | Recombinant mouse IL-1α |
| Reported Applications | in vivo IL-1α neutralization in vitro IL-1α neutralization |
| Formulation | PBS, pH 7.0 Contains no stabilizers or preservatives |
| Endotoxin | <2EU/mg (<0.002EU/μg) Determined by LAL gel clotting assay |
| Purity | >95% Determined by SDS-PAGE |
| Sterility | 0.2 µm filtration |
| Production | Purified from cell culture supernatant in an animal-free facility |
| Purification | Protein A |
| RRID | AB_2687724 |
| Molecular Weight | 150 kDa |
| Storage | The antibody solution should be stored at the stock concentration at 4°C. Do not freeze. |
组成成分
抗白细胞介素1蛋白抗体，磷酸盐缓冲液
应用
反应种属
mouse
背景
研究领域
Cell Migration & Adhesion, Cytokine and Chemokine, Immunology, Innate Immunity
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