IL-2 (D7A5) Rabbit mAb

Interleukin-2 (IL-2) is a T cell stimulatory cytokine best known for inducing T cell proliferation and NK cell proliferation and activation (1,2). IL-2 also promotes peripheral development of regulatory T cells (Tregs) (3,4). Conversely, IL-2 is involved in the activation-induced cell death (AICD) that is observed post T cell expansion by increasing levels of Fas on CD4+ T cells (5). The effects of IL-2 are mediated through a trimeric receptor complex consisting of IL-2Rα, IL-2Rβ, and the common gamma chain, γc (1,2). IL-2Rα binds exclusively to IL-2 with low affinity and increases the binding affinity of the whole receptor complex including IL-2Rβ and γc subunits. IL-15 also binds to IL-2Rβ (1,2). γc is used by other cytokines, including IL-4, IL-7, IL-9, IL-15, and IL-21 (1,2). Binding of IL-2 initiates signaling cascades involving Jak1, Jak3, Stat5, and the PI3K/Akt pathways (1,2). 1.Ma, A. et al. (2006) Annu Rev Immunol 24, 657-79. 2.Gaffen, S.L. and Liu, K.D. (2004) Cytokine 28, 109-23. 3.Fehérvari, Z. et al. (2006) Trends Immunol 27, 109-11. 4.Antony, P.A. et al. (2006) J Immunol 176, 5255-66. 5.Jaleco, S. et al. (2003) J Immunol 171, 61-8.