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产品介绍
产品介绍
产品信息
克隆号
5H4
克隆类别
单抗
Product Details
The 5H4 monoclonal antibody reacts with mouse CD122 also known as the IL-2 receptor beta chain. CD122 is a 70-75 kDa subunit of the IL-2 receptor and the IL-15 receptor. CD122 is expressed on NK cells and at lower levels by T lymphocytes, B lymphocytes, monocytes, and macrophages. The IL-2R has been shown to play roles in lymphocyte differentiation, activation, and proliferation. In complex with IL-2Rα, IL-2R binds IL-2 with relatively low affinity however, when CD122 combines with IL-2Rα and the common gamma chain (CD132) the complex binds IL-2 with high affinity. The 5H4 antibody does not inhibit binding of IL-2 to the IL-2R.Specifications
| Isotype | Rat IgG2a, κ |
|---|---|
| Recommended Isotype Control(s) | InVivoMAb rat IgG2a isotype control, anti-trinitrophenol |
| Recommended Dilution Buffer | InVivoPure pH 7.0 Dilution Buffer |
| Conjugation | This product is unconjugated. Conjugation is available via our Antibody Conjugation Services. |
| Immunogen | Rat myeloma YB2/0 transfected with truncated mouse CD122 cDNA |
| Reported Applications | in vitro NK cell negative selection Immunoprecipitation Flow cytometry |
| Formulation | PBS, pH 7.0 Contains no stabilizers or preservatives |
| Endotoxin | <2EU/mg (<0.002EU/μg) Determined by LAL gel clotting assay |
| Purity | >95% Determined by SDS-PAGE |
| Sterility | 0.2 µm filtration |
| Production | Purified from cell culture supernatant in an animal-free facility |
| Purification | Protein G |
| RRID | AB_2687795 |
| Molecular Weight | 150 kDa |
| Storage | The antibody solution should be stored at the stock concentration at 4°C. Do not freeze. |
组成成分
抗小鼠白细胞介素2受体 (IL-2Rβ)单克隆抗体
应用
反应种属
mouse
背景
研究领域
Cytokine Receptor, Immunology
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