Product Details

The TM-beta 1 monoclonal antibody reacts with mouse CD122 also known as the IL-2 receptor beta chain. CD122 is a 70-75 kDa subunit of the IL-2 receptor and the IL-15 receptor. CD122 is expressed on NK cells and at lower levels by T lymphocytes, B lymphocytes, monocytes, and macrophages. The IL-2R has been shown to play roles in lymphocyte differentiation, activation, and proliferation. In complex with IL-2Rα, IL-2R binds IL-2 with relatively low affinity however, when CD122 combines with IL-2Rα and the common gamma chain (CD132) the complex binds IL-2 with high affinity. The TM-beta 1 antibody is reported to inhibit binding of IL-2 to the IL-2R. Additionally, this antibody has been shown to deplete CD122 expressing NK cells with administered in vivo.

Specifications

Isotype	Rat IgG2b, κ
Recommended Isotype Control(s)	InVivoMAb rat IgG2b isotype control, anti-keyhole limpet hemocyanin
Recommended Dilution Buffer	InVivoPure pH 8.0 Dilution Buffer
Conjugation	This product is unconjugated. Conjugation is available via our Antibody Conjugation Services.
Immunogen	Mouse IL-2Rβ transfected cell line (TART-mβ cells)
Reported Applications	in vivo NK cell depletion in vivo CD122 blockade in vitro IL-2R blockade Functional assays Flow cytometry
Formulation	PBS, pH 8.0 Contains no stabilizers or preservatives
Endotoxin	<2EU/mg (<0.002EU/μg) Determined by LAL gel clotting assay
Purity	>95% Determined by SDS-PAGE
Sterility	0.2 µm filtration
Production	Purified from cell culture supernatant in an animal-free facility
Purification	Protein G
RRID	AB_2687820
Molecular Weight	150 kDa
Storage	The antibody solution should be stored at the stock concentration at 4°C. Do not freeze.

组成成分

白细胞介素蛋白抗体，磷酸盐缓冲液

应用

反应种属

mouse

背景

研究领域

Cytokine Receptor, Immunology

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货号：

BE0298-1MG

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