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产品介绍
产品介绍
产品信息
宿主
鼠
克隆号
3E12
克隆类别
单抗
Product Details
The 3E12 monoclonal antibody reacts with mouse CD132 also known as the common gamma chain and IL-2 receptor gamma chain. CD132 is a 64-70 kDa type I transmembrane glycoprotein belonging to the Ig superfamily. It is expressed by a wide range of cells including T and B lymphocytes, NK cells, monocytes, and granulocytes. CD132 is an essential subunit of the receptor complexes for at least six different interleukin receptors: IL-2, IL-4, IL-7, IL-9, IL-15 and IL-21 receptors. Ligand binding induces tyrosine phosphorylation and initiates signaling through the JAK/STAT pathway. The 3E12 antibody has been reported to block the bioactivity of IL-4, IL-9, and IL-15 and inhibit the ligand/receptor binding of IL-4 and IL-7.Specifications
| Isotype | Rat IgG2b |
|---|---|
| Recommended Isotype Control(s) | InVivoMAb rat IgG2b isotype control, anti-keyhole limpet hemocyanin |
| Recommended Dilution Buffer | InVivoPure pH 7.0 Dilution Buffer |
| Conjugation | This product is unconjugated. Conjugation is available via our Antibody Conjugation Services. |
| Immunogen | Rat myeloma YB2/0 transfected with mouse cytoplasmic-tailless CD132 |
| Reported Applications | in vivo γc blockade Functional assays Immunoprecipitation Flow cytometry |
| Formulation | PBS, pH 7.0 Contains no stabilizers or preservatives |
| Endotoxin | <2EU/mg (<0.002EU/μg) Determined by LAL gel clotting assay |
| Purity | >95% Determined by SDS-PAGE |
| Sterility | 0.2 μM filtered |
| Production | Purified from cell culture supernatant in an animal-free facility |
| Purification | Protein G |
| RRID | AB_2687794 |
| Molecular Weight | 150 kDa |
| Storage | The antibody solution should be stored at the stock concentration at 4°C. Do not freeze. |
组成成分
跨膜蛋白抗体，磷酸盐
应用
反应种属
mouse
背景
研究领域
Cytokine Receptor, Immunology
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