IL-6 (D5W4V) Rabbit mAb (Mouse Specific)

Acute phase response is induced by interleukin-6 (IL-6) produced by T cells, macrophages, fibroblasts, endothelial and other cells (1,2). IL-6 induces proliferation or differentiation in many cell types including B cells, thymocytes and T cells. IL-6, in concert with TGF-β, is important for developing Th17 responses. IL-6 binds to IL-6Rα and through this association induces gp130 homodimerization (1). gp130 homodimerization triggers the Jak/Stat cascade and the SHP-2/Erk MAP kinase cascade (1,3,4). IL-6 also forms a complex with an IL-6Rα splice variant that is non-membrane-associated (3). The IL-6/soluble IL-6Rα complex can then activate the gp130 signaling pathway in cells that express gp130 but not IL-6Rα (3). Research studies have shown that IL-6, through increasing expression of proangiogenic VEGF, may also contribute to metastatic breast cancer (5). 1.Heinrich, P.C. et al. (1998) Biochem J 334 (Pt 2), 297-314. 2.Heinrich, P.C. et al. (1998) Z Ernahrungswiss 37 Suppl 1, 43-9. 3.Jones, S.A. (2005) J Immunol 175, 3463-8. 4.Jenkins, B.J. et al. (2004) Mol Cell Biol 24, 1453-63. 5.Hong, D.S. et al. (2007) Cancer 110, 1911-28.