全部商品分类
.jpg)
1/2
用小程序，查商品更便捷
产品介绍
产品介绍
产品信息
抗原名称
PARP
商品描述
INO-1001是一种有效的PARP抑制剂，作用于CHO细胞的IC50为<50 nM，在再灌注期间，是一种因氧化诱导而发生的心肌功能障碍的调节剂。用浓度为0.05 到50 μM的INO-1001处理CHO细胞30分钟，明显抑制PARP 活性， IC50 为50 nM， INO-1001浓度为1 μM 或更高时抑制PARP活性达95%，且没有细胞毒性。此外, INO-1001通过阻断大部分受辐射的DNA片段修复而使CHO 细胞敏感。用400 μM H2O2处理后，通过增强乙酰胆碱诱导的, 依赖内皮细胞层的, NO调节的血管舒张，而提高INO-1001抑制PARP活性。
分子量
136.15
纯度
>98%
可溶性
Ethanol ：26 mg/mL (191 mM)
DMSO ：26 mg/mL (191 mM)
DMSO ：26 mg/mL (191 mM)
外观
white to off-white powder
In vitro(体外研究)
INO-1001 (>1 μM) leads to more than 95% inhibition of PARP activity without significant cellular toxicity. In addition, INO-1001 significantly sensitizes CHO cells by blocking most of the DNA repair occurring between radiation fractions. Inhibition of PARP activity by INO-1001 significantly improves endothelial function by enhancing the acetylcholine-induced, endothelium-dependent, nitric oxide mediated vasorelaxation after exposure with 400 μM H2O2.
In vivo(体内研究)
In a db/db (Leprdb/db) mouse model, INO-1001 ameliorates diabetes-induced albumin excretion and mesangial expansion, and also decreases diabetes-induced podocyte depletion. Treatment with INO-1001 (1.6 mg/kg via intracerebral injection) prevents NAD+ depletion and improves water maze performance after controlled cortical impact (CCI) in mice.
背景
别名
3-Aminobenzamide
分子式
C7H8N2O
CAS号
3544-24-9
制备和贮存
保存方式
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
声明 ：本官网所有报价均为常温或者蓝冰运输价格，如有产品需要干冰运输，需另外加收干冰运输费。