Product Details

The IR 83-22 monoclonal antibody reacts with human CD220, also known as insulin receptor. CD220 is a type I transmembrane receptor tyrosine kinase which, upon binding to insulin, initiates several cellular effects, including glucose uptake, cell growth, differentiation, and apoptosis. These effects primarily occur in skeletal muscle, fat, and the liver. Neuronal CD220 signaling has been shown to have an important role in energy homeostasis, reproduction, and the development of neurodegenerative diseases. The IR 83-22 antibody has been shown to inhibit approximately 80% of insulin binding to IM-9 insulin receptor expressing cells.

Specifications

Isotype	Mouse IgG1
Recommended Isotype Control(s)	InVivoMAb mouse IgG1 isotype control, unknown specificity
Recommended Dilution Buffer	InVivoPure pH 7.0 Dilution Buffer
Conjugation	This product is unconjugated. Conjugation is available via our Antibody Conjugation Services.
Immunogen	Human IM-9 lymphocytes
Reported Applications	Western blot
Formulation	PBS, pH 7.0 Contains no stabilizers or preservatives
Endotoxin	<2EU/mg (<0.002EU/μg) Determined by LAL gel clotting assay
Purity	>95% Determined by SDS-PAGE
Sterility	0.2 μM filtered
Production	Purified from cell culture supernatant in an animal-free facility
Purification	Protein G
RRID	AB_2894758
Molecular Weight	150 kDa
Storage	The antibody solution should be stored at the stock concentration at 4°C. Do not freeze.

组成成分

IGG-免疫球蛋白G型抗体

应用

反应种属

Human

背景

研究领域

Tumor Antigens

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货号：

BE0338-1MG

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