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Obeticholic acid
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产品介绍
产品介绍
产品信息
抗原名称
FXR
商品描述
INT-747(Obeticholic acid; 6-ECDCA) is a potent and selective FXR agonist(EC50=99 nM) endowed with anticholestatic activity.
分子量
420.63
纯度
>98%
可溶性
DMSO：84 mg/mL (199.7 mM)
Ethanol：84 mg/mL warmed (199.7 mM)
Ethanol：84 mg/mL warmed (199.7 mM)
外观
white powder
In vitro(体外研究)
In HuH7 cells, Obeticholic Acid acts as a potent FXR agonist with EC50 of 85 nM.
In vivo(体内研究)
In rat cholestasis model, Obeticholic Acid promotes bile flow, and protects hepatocytes against acute necrosis caused by LCA. Obeticholic Acid (p.o.) improves proteinuria, ameliorates renal structural changes, and modulates renal inflammation and oxidative stress in WD-fed DBA mice. In thioacetamide (TAA)-intoxicated and bile-duct-ligated (BDL) rats, Obeticholic Acid (30 mg/kg p.o.) reactivates the FXR downstream signaling pathway and decreases portal pressure by lowering total IHVR without deleterious systemic hypotension.
背景
别名
奥贝胆酸
分子式
C26H44O4
CAS号
459789-99-2
制备和贮存
保存方式
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
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