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产品介绍
产品介绍
产品信息
克隆号
LX-CT10.5
Product Details
The LX-CT10.5 monoclonal antibody reacts with human melanoma-associated antigen C2 (MAGEC2), also known as CT10 and HCA587. MAGEC2 is one of many cancer/testis (CT)-antigens. CT antigens are thought to repress the expression of some genes necessary for cellular differentiation. Normally, MAGEC2 expression is restricted to male germ cells in the testis however, MAGE-C2 is abnormally expressed in a wide variety of malignancies, including hepatocellular carcinoma, melanoma, bladder cancer, breast cancer, sarcoma, and lung cancer. MAGEC2 positive tumors are associated with reduced overall survival rates in prostate, hepatocellular, breast, and non-small cell lung carcinomas. Since MAGEC2 is highly expressed in cancer cells but absent from normal adult tissues it is considered an ideal target for cancer immunotherapy. The LX-CT10.5 antibody is useful for identifying MAGEC2 expressing cells in immunohistochemical studies.Specifications
| Isotype | Mouse IgG2a, κ |
|---|---|
| Recommended Isotype Control(s) | InVivoMAb mouse IgG2a isotype control, unknown specificity |
| Recommended Dilution Buffer | InVivoPure pH 7.0 Dilution Buffer |
| Conjugation | This product is unconjugated. Conjugation is available via our Antibody Conjugation Services. |
| Immunogen | CT10/MAGE-C2 protein |
| Reported Applications | Immunohistochemistry (paraffin) Immunofluorescence Western blot |
| Formulation | PBS, pH 7.0 Contains no stabilizers or preservatives |
| Endotoxin | <2EU/mg (<0.002EU/μg) Determined by LAL gel clotting assay |
| Purity | >95% Determined by SDS-PAGE |
| Sterility | 0.2 μM filtered |
| Production | Purified from cell culture supernatant in an animal-free facility |
| Purification | Protein A |
| RRID | AB_2894755 |
| Molecular Weight | 150 kDa |
| Storage | The antibody solution should be stored at the stock concentration at 4°C. Do not freeze. |
组成成分
IGG-免疫球蛋白G型抗体
应用
反应种属
Human
背景
研究领域
Cancer Biology
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