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产品介绍
产品介绍
产品信息
荧光素标记
来源纯化
Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Ala140 of human IP6K3 protein.
宿主
Rabbit
商品描述
Product Usage Information
| Application | Dilution |
|---|---|
| Western Blotting | 1:1000 |
| Immunoprecipitation | 1:50 |
同种型
Rabbit IgG
分子量
46
应用
目标/特异性
Specificity/Sensitivity
IP6K3 (D9O7J) Rabbit mAb recognizes endogenous levels of total IP6K3 protein. This antibody does not cross-react with IP6K1 or IP6K2 proteins.
Species Reactivity:
Human
敏感性
Endogenous
背景
背景
Inositol hexakisphosphate kinase 3 (IP6K3) is a member of the inositol hexakisphosphate kinase family (1). These kinases are essential for producing inositol pyrophosphates (1). IP6K3 is highly expressed in the cerebellar Purkinje cells, interacts with adducin and spectrin, and plays an important role in determining the cytoskeletal organization and function of these cells (1). In addition, the expression of IP6K3 increases upon treatment with titanium dioxide nanoparticles suggesting a role for IP6K3 in the genotoxicity caused by these nanoparticles (2).
1.Fu, C. et al. (2015) J Neurosci 35, 11056-67.
2.El-Said, K.S. et al. (2014) J Nanobiotechnology 12, 48.
研究领域
癌症,代谢,神经科学
翻译后修饰
unmodified
制备和贮存
保存方式
Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.
数据库链接
Entrez-Gene ID
117283
UniProt ID
Q96PC2
参考图片
Immunoprecipitation of IP6K3 from HepG2 cell extracts. Lane 1 is 10% input, lane 2 is Rabbit (DA1E) mAb IgG XP® Isotype Control #3900, and lane 3 is IP6K3 (D9O7J) Rabbit mAb. Western blot analysis was performed using IP6K3 (D9O7J) Rabbit mAb.
Western blot analysis of extracts from various cell lines using IP6K3 (D9O7J) Rabbit mAb.
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