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CD11alpha (E5S9K) Rabbit mAb (BSA and Azide Free)

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CD11alpha (E5S9K) Rabbit mAb (BSA and Azide Free)

品牌： CST

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产品介绍

产品信息

荧光素标记

Unconjugated

来源纯化

Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Val975 of human CD11α protein.

宿主

Rabbit

商品描述

Product Usage Information

This product is the carrier free version of product #26703. All data were generated using the same antibody clone in the standard formulation which contains BSA and glycerol.

This formulation is ideal for use with technologies requiring specialized or custom antibody labeling, including fluorophores, metals, lanthanides, and oligonucleotides. It is not recommended for ChIP, ChIP-seq, CUT&RUN or CUT&Tag assays. If you require a carrier free formulation for chromatin profiling, please contact us. Optimal dilutions/concentrations should be determined by the end user.

BSA and Azide Free antibodies are quality control tested by size exclusion chromatography (SEC) to determine antibody integrity.

同种型

Rabbit IgG

分子量

160

备注

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应用

目标/特异性

Specificity/Sensitivity

CD11α (E5S9K) Rabbit mAb (BSA and Azide Free) recognizes endogenous levels of total CD11α protein.

Species Reactivity:

Human

敏感性

Endogenous

背景

CD11α, also known as integrin alpha-L (ITGAL), is the alpha chain of the lymphocyte function-associated antigen-1 (LFA-1). CD11α combines with the beta chain CD18 (ITGB2) to form LFA-1, an integrin expressed on all leukocytes. LFA-1 plays a central role in leukocyte intercellular adhesion through interactions with its ligands ICAM-1, 2, 3, and 4 (1), F11R/JAM-1 (2,3), and the secreted form of ubiquitin-like protein ISG15 (4). LFA-1 is involved in a variety of immune phenomena including leukocyte-endothelial cell interaction and transmigration (2,3), cytotoxic T cell co-stimulation (5), cytotoxic NK cell mediated killing (6), leukocyte clearance (7), and antibody-dependent killing by granulocytes and monocytes (8,9). LFA-1 is required for generation of common lymphoid progenitor cells in bone marrow, indicating a role in lymphopoiesis (10). High expression of CD11α has been associated with antigen-specific and tumor-reactive T cells (11,12). 1.Hynes, R.O. (1992) Cell 69, 11-25. 2.Ostermann, G. et al. (2002) Nat Immunol 3, 151-8. 3.Fraemohs, L. et al. (2004) J Immunol 173, 6259-64. 4.Swaim, C.D. et al. (2017) Mol Cell 68, 581-590.e5. 5.Ni, H.T. et al. (2001) J Immunol 166, 6523-9. 6.Barber, D.F. et al. (2004) J Immunol 173, 3653-9. 7.Kristóf, E. et al. (2013) Apoptosis 18, 1235-51. 8.Springer, T.A. et al. (1985) Adv Exp Med Biol 184, 311-22. 9.Kohl, S. et al. (1984) J Immunol 133, 2972-8. 10.Bose, T.O. et al. (2014) J Immunol 193, 2863-72. 11.Liu, X. et al. (2013) Oncoimmunology 2, e23972. 12.Christiaansen, A.F. et al. (2017) Vaccine 35, 4255-61.

翻译后修饰

unmodified

制备和贮存

保存方式

Store at -20°C. This product will freeze at -20°C so it is recommended to aliquot into single-use vials to avoid multiple freeze/thaw cycles. A slight precipitate may be present and can be dissolved by gently vortexing. This will not interfere with antibody performance.

数据库链接

Entrez-Gene ID

3683

UniProt ID

P20701

参考图片

Immunohistochemical analysis of paraffin-embedded human T-cell lymphoma using CD11α (E5S9K) Rabbit mAb. Data were generated using the standard formulation of this product.

Western blot analysis of extracts from HeLa and Jurkat cells using CD11α (E5S9K) Rabbit mAb (upper) and β-Actin (D6A8) Rabbit mAb #8457 (lower). Data were generated using the standard formulation of this product.

Immunohistochemical analysis of paraffin-embedded human squamous cell carcinoma of the tonsil using CD11α (E5S9K) Rabbit mAb. Data were generated using the standard formulation of this product.

Immunohistochemical analysis of paraffin-embedded human prostate carcinoma using CD11α (E5S9K) Rabbit mAb. Data were generated using the standard formulation of this product.

Immunohistochemical analysis of paraffin-embedded human tonsil using CD11α (E5S9K) Rabbit mAb. Data were generated using the standard formulation of this product.

Immunohistochemical analysis of paraffin-embedded human ductal breast carcinoma using CD11α (E5S9K) Rabbit mAb. Data were generated using the standard formulation of this product.

Immunohistochemical analysis of paraffin-embedded RL cell pellet (left, positive) or HeLa cell pellet (right, negative) using CD11α (E5S9K) Rabbit mAb. Data were generated using the standard formulation of this product.

Immunohistochemical analysis of paraffin-embedded human colon carcinoma using CD11α (E5S9K) Rabbit mAb (left) compared to concentration-matched Rabbit (DA1E) mAb IgG XP® Isotype Control #3900 (right). Data were generated using the standard formulation of this product.

Immunohistochemical analysis of paraffin-embedded human esophageal adenocarcinoma using CD11α (E5S9K) Rabbit mAb. Data were generated using the standard formulation of this product.

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货号：

36769SF

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询价

100ug

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